{"id":"225eca5c-c9d3-5de1-b5e1-9fef1781eb77","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:wholewheat-lysine-availability","predicate":"has_measured_metabolic_availability","statement":"The tested whole-wheat bread supplied lysine with an estimated 90% metabolic availability, while low lysine concentration still limited its protein quality.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"625af4e9-6a9e-550f-af17-e293e6849f73","mechanism_event_label":"A food can deliver most of its lysine efficiently yet contain too little lysine relative to other amino acids.","subject":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"object":{"id":"b58766e3-ba8d-5af6-b940-b65948155b5b","slug":"lysine-metabolic-availability","display_name":"Lysine metabolic availability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"625af4e9-6a9e-550f-af17-e293e6849f73","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:wholewheat-lysine-availability-event","event_type":"observed_intervention","label":"A food can deliver most of its lysine efficiently yet contain too little lysine relative to other amino acids.","description":"The tested whole-wheat bread supplied lysine with an estimated 90% metabolic availability, while low lysine concentration still limited its protein quality.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"tested_amino_acid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b58766e3-ba8d-5af6-b940-b65948155b5b","slug":"lysine-metabolic-availability","display_name":"Lysine metabolic availability","entity_type_key":"cellular_process"},"role":"measured_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Randomized intake-order repeated-measures experiment in five young men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lysine supplied by the tested whole-wheat bread; bread is a food matrix recorded in context, not a chemical-species entity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specific bread and small sample; metabolic availability is method-dependent and does not establish adequacy of all wheat-based diets.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A food can deliver most of its lysine efficiently yet contain too little lysine relative to other amino acids.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[tulnoor2025] Lysine from Whole Wheat Bread Consumed by Healthy Adult Males Has High Metabolic Availability When Assessed Using the Indicator Amino Acid Oxidation Method (2025). https://pubmed.ncbi.nlm.nih.gov/39163973/ DOI: 10.1016/j.tjnut.2024.08.011","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-body amino-acid metabolism","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"523ad2a3-4fe6-50ca-a373-17a44b760bf6","evidence_kind":"source_excerpt","locator":"Lines 648-657","start_line":648,"end_line":657,"excerpt":"### wholewheat-lysine-availability\nThe tested whole-wheat bread supplied lysine with an estimated 90% metabolic availability, while low lysine concentration still limited its protein quality.\nPlain language: A food can deliver most of its lysine efficiently yet contain too little lysine relative to other amino acids.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Whole-body amino-acid metabolism\nexperimental_model: Randomized intake-order repeated-measures experiment in five young men\nlimitations: Specific bread and small sample; metabolic availability is method-dependent and does not establish adequacy of all wheat-based diets.\nexposure: Lysine supplied by the tested whole-wheat bread; bread is a food matrix recorded in context, not a chemical-species entity.\n[tulnoor2025] Lysine from Whole Wheat Bread Consumed by Healthy Adult Males Has High Metabolic Availability When Assessed Using the Indicator Amino Acid Oxidation Method (2025). https://pubmed.ncbi.nlm.nih.gov/39163973/ DOI: 10.1016/j.tjnut.2024.08.011","model_system":"Randomized intake-order repeated-measures experiment in five young men","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [tulnoor2025] Lysine from Whole Wheat Bread Consumed by Healthy Adult Males Has High Metabolic Availability When Assessed Using the Indicator Amino Acid Oxidation Method (2025). https://pubmed.ncbi.nlm.nih.gov/39163973/ DOI: 10.1016/j.tjnut.2024.08.011","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}