{"id":"225cef6c-bd7a-575a-9e43-4a141b0f295d","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-single-immersion-immune","predicate":"preserves_measured_pool","statement":"The effect of a single cold water immersion at 14 degrees C for 1 hour on the immune system, monitored immediately after immersion, was minimal.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"f840f039-f204-5af6-966d-9fe49ae374ac","mechanism_event_label":"One cold plunge does essentially nothing measurable to the immune system.","subject":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"object":{"id":"7c5d1c30-425c-52c4-9c1e-3206b83a8dbb","slug":"monocyte-proportion","display_name":"Proportion of circulating monocytes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f840f039-f204-5af6-966d-9fe49ae374ac","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-single-immersion-immune-event","event_type":"observed_intervention","label":"One cold plunge does essentially nothing measurable to the immune system.","description":"The effect of a single cold water immersion at 14 degrees C for 1 hour on the immune system, monitored immediately after immersion, was minimal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7c5d1c30-425c-52c4-9c1e-3206b83a8dbb","slug":"monocyte-proportion","display_name":"Proportion of circulating monocytes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/8925815.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ca491f2f549a1e245e952978c0df82c4075622affdf114a70315c0cce8583ff4\", \"start_char\": 0, \"end_char\": 1732, \"text_sha256\": \"ca491f2f549a1e245e952978c0df82c4075622affdf114a70315c0cce8583ff4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Athletic young men given a single immersion and then repeated immersions over six weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"14 degrees C for 1 hour, three times a week for six weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The authors themselves state the biological significance of the changes remains to be elucidated. Most immune measures did not change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One cold plunge does essentially nothing measurable to the immune system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p8925815] Immune system of cold-exposed and cold-adapted humans. (1996). https://pubmed.ncbi.nlm.nih.gov/8925815/ DOI: 10.1007/bf00242274","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Immune system","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6ee76bff-ae7e-5a0c-a2fc-02cedb494d89","evidence_kind":"source_excerpt","locator":"Lines 702-713","start_line":702,"end_line":713,"excerpt":"### cold-single-immersion-immune\nThe effect of a single cold water immersion at 14 degrees C for 1 hour on the immune system, monitored immediately after immersion, was minimal.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: One cold plunge does essentially nothing measurable to the immune system.\norganism: Human\ntissue_or_cell_type: Immune system\nexperimental_model: Athletic young men given a single immersion and then repeated immersions over six weeks\nlimitations: The authors themselves state the biological significance of the changes remains to be elucidated. Most immune measures did not change.\nexposure: 14 degrees C for 1 hour, three times a week for six weeks\nevidence_span: {\"source_cache\": \"artifacts/cold-research/8925815.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ca491f2f549a1e245e952978c0df82c4075622affdf114a70315c0cce8583ff4\", \"start_char\": 0, \"end_char\": 1732, \"text_sha256\": \"ca491f2f549a1e245e952978c0df82c4075622affdf114a70315c0cce8583ff4\"}\n[cold-p8925815] Immune system of cold-exposed and cold-adapted humans. (1996). https://pubmed.ncbi.nlm.nih.gov/8925815/ DOI: 10.1007/bf00242274","model_system":"Athletic young men given a single immersion and then repeated immersions over six weeks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cold-p8925815] Immune system of cold-exposed and cold-adapted humans. (1996). https://pubmed.ncbi.nlm.nih.gov/8925815/ DOI: 10.1007/bf00242274","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"feeccadc-1392-573e-a0b5-0939ee5de6e2","stable_key":"import-b3c3f45a-50fb-5b79-98d7-5e5228df00db","title":"Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"557f074d372c49c502c34e648651aff7ebf2c8816305d2d2f08e338a7e96a5f0","revision_id":"ecc19e8d-40db-5b5d-b98e-0507f645976c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}