{"id":"224f0ae7-4451-52bd-b0d6-998e55e6f63f","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-cold-noradrenaline-rise","predicate":"increases","statement":"Plasma noradrenaline and dopamine concentrations increased by 530% and 250% at 14 degrees C, while plasma adrenaline concentrations remained unchanged and cortisol tended to decrease.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"91eeb793-0ccb-5bf7-82f3-f688bea39a54","mechanism_event_label":"Cold water multiplies one messenger sixfold and leaves adrenaline and cortisol alone.","subject":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"object":{"id":"14452a0d-37f0-544d-8cc2-0b770a16b5d3","slug":"plasma-noradrenaline","display_name":"Plasma noradrenaline concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"91eeb793-0ccb-5bf7-82f3-f688bea39a54","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-cold-noradrenaline-rise-event","event_type":"observed_intervention","label":"Cold water multiplies one messenger sixfold and leaves adrenaline and cortisol alone.","description":"Plasma noradrenaline and dopamine concentrations increased by 530% and 250% at 14 degrees C, while plasma adrenaline concentrations remained unchanged and cortisol tended to decrease.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a502ad42-2c27-5e54-9f16-c57b3c6faf41","slug":"plasma-dopamine","display_name":"Plasma dopamine concentration","entity_type_key":"cellular_process"},"role":"co_measured","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c9ce8232-0942-536d-ae55-e0d974f82d7b","slug":"plasma-adrenaline","display_name":"Plasma adrenaline concentration","entity_type_key":"cellular_process"},"role":"unchanged_measure","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b206e39e-112c-558b-91b6-16504d0c518e","slug":"cortisol","display_name":"Cortisol","entity_type_key":"small_molecule"},"role":"unchanged_measure","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"14452a0d-37f0-544d-8cc2-0b770a16b5d3","slug":"plasma-noradrenaline","display_name":"Plasma noradrenaline concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/10751106.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\", \"start_char\": 0, \"end_char\": 2332, \"text_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Young men during 1-hour head-out immersions at 32, 20 and 14 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One hour head-out immersion at three water temperatures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The thermoneutral arm separates hydrostatic pressure from cold. Cortisol did not rise at any temperature, which bears directly on calling immersion a stress response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Cold water multiplies one messenger sixfold and leaves adrenaline and cortisol alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p10751106] Human physiological responses to immersion into water of different temperatures. (2000). https://pubmed.ncbi.nlm.nih.gov/10751106/ DOI: 10.1007/s004210050065","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole body","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5d505e99-43e4-56fe-a4d8-a3984e3d8876","evidence_kind":"source_excerpt","locator":"Lines 195-206","start_line":195,"end_line":206,"excerpt":"### cold-cold-noradrenaline-rise\nPlasma noradrenaline and dopamine concentrations increased by 530% and 250% at 14 degrees C, while plasma adrenaline concentrations remained unchanged and cortisol tended to decrease.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: Cold water multiplies one messenger sixfold and leaves adrenaline and cortisol alone.\norganism: Human\ntissue_or_cell_type: Whole body\nexperimental_model: Young men during 1-hour head-out immersions at 32, 20 and 14 degrees C\nlimitations: The thermoneutral arm separates hydrostatic pressure from cold. Cortisol did not rise at any temperature, which bears directly on calling immersion a stress response.\nexposure: One hour head-out immersion at three water temperatures\nevidence_span: {\"source_cache\": \"artifacts/cold-research/10751106.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\", \"start_char\": 0, \"end_char\": 2332, \"text_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\"}\n[cold-p10751106] Human physiological responses to immersion into water of different temperatures. (2000). https://pubmed.ncbi.nlm.nih.gov/10751106/ DOI: 10.1007/s004210050065","model_system":"Young men during 1-hour head-out immersions at 32, 20 and 14 degrees C","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cold-p10751106] Human physiological responses to immersion into water of different temperatures. (2000). https://pubmed.ncbi.nlm.nih.gov/10751106/ DOI: 10.1007/s004210050065","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"feeccadc-1392-573e-a0b5-0939ee5de6e2","stable_key":"import-b3c3f45a-50fb-5b79-98d7-5e5228df00db","title":"Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"557f074d372c49c502c34e648651aff7ebf2c8816305d2d2f08e338a7e96a5f0","revision_id":"ecc19e8d-40db-5b5d-b98e-0507f645976c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}