{"id":"2231f9b7-ebb1-5781-82cb-f59bcbac32e2","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-human-concentration","predicate":"associated_with_impairment","statement":"Urine-concentrating impairment and lower urinary AQP2/cAMP correlated with lithium-treatment duration in patients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"517d7e3f-bdad-573a-8e9a-22b5db76916f","mechanism_event_label":"Human kidney findings connect the cellular route to water balance.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"40d861d6-c873-5a0b-9786-acd40cad5f97","slug":"human-lithium-urine-concentration","display_name":"Human urine-concentrating response during lithium treatment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"517d7e3f-bdad-573a-8e9a-22b5db76916f","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-human-concentration-event","event_type":"observed_relationship","label":"Human kidney findings connect the cellular route to water balance.","description":"Urine-concentrating impairment and lower urinary AQP2/cAMP correlated with lithium-treatment duration in patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40d861d6-c873-5a0b-9786-acd40cad5f97","slug":"human-lithium-urine-concentration","display_name":"Human urine-concentrating response during lithium treatment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0cf1432e-2f5f-542c-8980-6894da46cce6","slug":"aqp2","display_name":"Aquaporin-2 / AQP2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"9cc3323e-3a7f-5be5-91ae-78dab284fb81","slug":"cyclic-amp","display_name":"Cyclic adenosine monophosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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