{"id":"21fa8208-e009-5547-8e00-8f501a9f2337","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-singlet-quenching","predicate":"quenches","statement":"Lutein quenched singlet oxygen in the solution assay comparing individual macular carotenoids and mixtures.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e310e2f2-1231-578d-a0e8-e3781629a3d9","mechanism_event_label":"Lutein can reduce excited oxygen in a chemical experiment.","subject":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"object":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"e310e2f2-1231-578d-a0e8-e3781629a3d9","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-singlet-quenching-event","event_type":"biochemical_relationship","label":"Lutein can reduce excited oxygen in a chemical experiment.","description":"Lutein quenched singlet oxygen in the solution assay comparing individual macular carotenoids and mixtures.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/20678467.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"aaf88f567941ed16adb101981a218960bbd8ae3cfe0919868de63462e7c7be01\", \"start_char\": 0, \"end_char\": 989, \"text_sha256\": \"aaf88f567941ed16adb101981a218960bbd8ae3cfe0919868de63462e7c7be01\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"EPR of donor eye tissue and solution quenching assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"White-light challenge and equal-total-concentration carotenoid comparisons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Solution mixture effects do not establish an optimal oral ratio or clinical benefit; exogenous pigment addition differs from delivery in a living eye.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Postmortem human tissue and cell-free systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lutein can reduce excited oxygen in a chemical experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p20678467] Studies on the singlet oxygen scavenging mechanism of human macular pigment. 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