{"id":"21efb951-32af-55dc-9cb6-f3c8b1d67ffd","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:very-low-mg-enhances-casr-camp-inhibition","predicate":"depletion-lowers","statement":"Low Mg enhanced CaSR-associated inhibition of cAMP in the tested parathyroid and receptor-expression cell systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a46356ed-8270-5895-a1c9-1fefcd87dc51","mechanism_event_label":"Low Mg strengthened a signaling arm that reduces the cAMP signal associated with PTH release.","subject":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"object":{"id":"9cc3323e-3a7f-5be5-91ae-78dab284fb81","slug":"cyclic-amp","display_name":"Cyclic adenosine monophosphate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a46356ed-8270-5895-a1c9-1fefcd87dc51","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:very-low-mg-enhances-casr-camp-inhibition-event","event_type":"biochemical_relationship","label":"Low Mg strengthened a signaling arm that reduces the cAMP signal associated with PTH release.","description":"Low Mg enhanced CaSR-associated inhibition of cAMP in the tested parathyroid and receptor-expression cell systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1c0d5c58-d358-5501-9bdf-8999bcf79fd4","slug":"casr","display_name":"Calcium-sensing receptor / CaSR","entity_type_key":"protein"},"role":"receptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1ca418db-3137-5dba-8ae2-8941432f0156","slug":"g-alpha-i-o","display_name":"Gi/o-family G protein alpha subunits","entity_type_key":"protein_family"},"role":"inhibitory signaling proteins","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9cc3323e-3a7f-5be5-91ae-78dab284fb81","slug":"cyclic-amp","display_name":"Cyclic adenosine monophosphate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [quitterer-2001-magnesium-paradox] Paradoxical block of parathormone secretion is mediated by increased activity of G alpha subunits (2001). https://pubmed.ncbi.nlm.nih.gov/11102444/ DOI: 10.1074/jbc.M007727200","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}