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Supplements were not independently inspected. These results constrain a hypothesis; they do not test SLC25A39 loss or establish its bypass. Exact iron sensor and transporter substrate remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_locator","value_text":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10329284/ Figure 6K/L","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"https://doi.org/10.1016/j.molcel.2023.05.031","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c4f3b7af-657d-544a-98c4-366acb40ff09","evidence_kind":"source_excerpt","locator":"Lines 20-31","start_line":20,"end_line":31,"excerpt":"ABCB7 knockdown reduced DELE1 stabilization during iron chelation.\nprimary_references: https://doi.org/10.1016/j.molcel.2023.05.031\nprimary_locator: https://pmc.ncbi.nlm.nih.gov/articles/PMC10329284/ Figure 6K/L\nevidence_cache: artifacts/discovery-research/round2-sources/iscu-counterevidence-search.json; SHA256 91e6dd454b1fdecf0cf4d29d2579bf1eba148109e446059f91ea966f8bf0de21\naccess_level: selected_indexed_full_text_passages\norganism: Human\nexperimental_model: Endogenous DELE1-HA HEK293T\nduration: 72-hour siRNA; DFO for 16 hours; CHX chase final 30 minutes\nexposure: DFO and CHX concentrations unresolved\ndose: Unresolved; not inferred from another panel\nendpoint: DELE1 protein stability immunoblot readout\nlimitations: Selected primary Results and figure legends accessed through indexed text. Supplements were not independently inspected. These results constrain a hypothesis; they do not test SLC25A39 loss or establish its bypass. Exact iron sensor and transporter substrate remain unresolved.","model_system":"Endogenous DELE1-HA HEK293T","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Authored paraphrase with primary locator and unresolved conditions.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"eeffd0c6-7b5e-5ec2-944b-6db3981fb281","stable_key":"import-0a78b350-a082-585a-984b-3a9f329e1574","title":"Requirements for iron-triggered DELE1 signaling","document_type":"imported_text","citation_label":"Primary study 10.1016/j.molcel.2023.05.031; targeted counterevidence curation, 2026-09-20.","file_path":"","sha256":"a51546326ca2ae4bbae2be44808672a526607fc7b68ade25f143a7a93cc08cf0","revision_id":"0d367584-8f47-5eda-946d-3d9f780b9b74","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}