{"id":"2198873a-981e-5526-8ef8-c73cd90db549","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-glycemia-trial-limit","predicate":"does_not_show_reported_group_impairment","statement":"Significant group-level glycemic impairment was reported for saccharin and sucralose, not aspartame, in the two-week trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"894c571a-da08-50b7-961e-32a7c04a904f","mechanism_event_label":"The result for one sweetener cannot be assigned to all of them.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"03ba901a-5a20-59c8-951c-b8ccf70155cb","slug":"human-aspartame-glycemic-response","display_name":"Human glycemic response in the two-week aspartame trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"894c571a-da08-50b7-961e-32a7c04a904f","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-glycemia-trial-limit-event","event_type":"observed_relationship","label":"The result for one sweetener cannot be assigned to all of them.","description":"Significant group-level glycemic impairment was reported for saccharin and sucralose, not aspartame, in the two-week trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"03ba901a-5a20-59c8-951c-b8ccf70155cb","slug":"human-aspartame-glycemic-response","display_name":"Human glycemic response in the two-week aspartame trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same randomized human trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short duration and person-specific variation limit inference; not proof of no possible long-term effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The result for one sweetener cannot be assigned to all of them.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35987213/ · DOI 10.1016/j.cell.2022.07.016","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ad18f0d3-cd7d-559b-9022-f26f0689c3d4","evidence_kind":"source_excerpt","locator":"Lines 298-304","start_line":298,"end_line":304,"excerpt":"## aspartame-glycemia-trial-limit\nThe result for one sweetener cannot be assigned to all of them.\nSignificant group-level glycemic impairment was reported for saccharin and sucralose, not aspartame, in the two-week trial.\nModel: Same randomized human trial.\nLimitations: Short duration and person-specific variation limit inference; not proof of no possible long-term effect.\nEvidence access: Primary abstract\nPersonalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35987213/ · DOI 10.1016/j.cell.2022.07.016","model_system":"Same randomized human trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"21cfc6808062c6ea1fb5d34128bcd005d31f0f6c0d63484794238db77d32ae97","revision_id":"1255dda8-df99-5d4b-a65b-4144c47d7d9b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}