{"id":"218aa127-777a-54a9-a642-8b86f050ed3b","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-urine-k","predicate":"increases","statement":"Total potassium output increased over the two-hour post-caffeine collection.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7863ac45-c2eb-5b8c-8e1a-a7cbeda7079c","mechanism_event_label":"Potassium output also changed in the short collection.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"7f78edef-2ff6-5c96-b8ff-dc3f48fb80cd","slug":"urinary-potassium-excretion","display_name":"Urinary potassium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7863ac45-c2eb-5b8c-8e1a-a7cbeda7079c","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-urine-k-event","event_type":"observed_relationship","label":"Potassium output also changed in the short collection.","description":"Total potassium output increased over the two-hour post-caffeine collection.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7f78edef-2ff6-5c96-b8ff-dc3f48fb80cd","slug":"urinary-potassium-excretion","display_name":"Urinary potassium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract did not report a significant potassium/creatinine ratio change; total output must not be confused with selective potassium wasting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Potassium output also changed in the short collection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of dietary caffeine on renal handling of minerals in adult women. · 1990 · https://pubmed.ncbi.nlm.nih.gov/2402180/ · DOI 10.1016/0024-3205(90)90616-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"41c1558e-ada5-5a29-bb60-9315fbfede27","evidence_kind":"source_excerpt","locator":"Lines 332-338","start_line":332,"end_line":338,"excerpt":"## caf-urine-k\nPotassium output also changed in the short collection.\nTotal potassium output increased over the two-hour post-caffeine collection.\nModel: 37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.\nLimitations: The abstract did not report a significant potassium/creatinine ratio change; total output must not be confused with selective potassium wasting.\nEvidence access: Primary abstract\nEffects of dietary caffeine on renal handling of minerals in adult women. · 1990 · https://pubmed.ncbi.nlm.nih.gov/2402180/ · DOI 10.1016/0024-3205(90)90616-y","model_system":"37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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