{"id":"21760c89-a72b-53b1-ad39-a0f882f2865e","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-msh2-context","predicate":"modulates","statement":"Carbohydrate-derived microbial metabolites including butyrate fueled hyperproliferation of Msh2-deficient colonic epithelium in the Apc-mutant mouse cancer model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"50818518-fe6a-5edd-9261-68b9201e7b76","mechanism_event_label":"A genetically altered epithelium could use the metabolite to support abnormal growth.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"10c4ad27-d019-5503-9c87-ce800a054288","slug":"mouse-msh2-deficient-epithelial-proliferation","display_name":"Proliferation of Apc/Msh2-deficient mouse colonic epithelium","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"50818518-fe6a-5edd-9261-68b9201e7b76","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-msh2-context-event","event_type":"observed_relationship","label":"A genetically altered epithelium could use the metabolite to support abnormal growth.","description":"Carbohydrate-derived microbial metabolites including butyrate fueled hyperproliferation of Msh2-deficient colonic epithelium in the Apc-mutant mouse cancer model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"10c4ad27-d019-5503-9c87-ce800a054288","slug":"mouse-msh2-deficient-epithelial-proliferation","display_name":"Proliferation of Apc/Msh2-deficient mouse colonic epithelium","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Apc-mutant/Msh2-deficient mice; dietary and microbial perturbation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genotype-specific model, not proof that butyrate causes cancer in healthy humans or that fiber should be avoided. Correction record: A published erratum is confirmed by PubMed and publisher/Crossref metadata: Cell 159(2):456, 2014. The notice body was not available through the accessed publisher endpoints, so its specific impact has not been assessed. The abstract-based MSH2 claim remains provisional with this unresolved correction flag. https://doi.org/10.1016/j.cell.2014.09.041","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A genetically altered epithelium could use the metabolite to support abnormal growth.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25036629/ · DOI 10.1016/j.cell.2014.04.051","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f1754195-2f69-5938-8e2b-71ac62f529dc","evidence_kind":"source_excerpt","locator":"Lines 638-644","start_line":638,"end_line":644,"excerpt":"## butyrate-msh2-context\nA genetically altered epithelium could use the metabolite to support abnormal growth.\nCarbohydrate-derived microbial metabolites including butyrate fueled hyperproliferation of Msh2-deficient colonic epithelium in the Apc-mutant mouse cancer model.\nModel: Apc-mutant/Msh2-deficient mice; dietary and microbial perturbation.\nLimitations: Genotype-specific model, not proof that butyrate causes cancer in healthy humans or that fiber should be avoided. Correction record: A published erratum is confirmed by PubMed and publisher/Crossref metadata: Cell 159(2):456, 2014. The notice body was not available through the accessed publisher endpoints, so its specific impact has not been assessed. The abstract-based MSH2 claim remains provisional with this unresolved correction flag. https://doi.org/10.1016/j.cell.2014.09.041\nEvidence access: Primary abstract\nGut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25036629/ · DOI 10.1016/j.cell.2014.04.051","model_system":"Apc-mutant/Msh2-deficient mice; dietary and microbial perturbation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}