{"id":"213447e6-ccae-53bd-b8f0-c2d90ad523e3","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-microbial-growth-selectivity","predicate":"differentially_changes","statement":"Naringenin severely inhibited Enterococcus caccae, slightly enhanced Bifidobacterium catenulatum, and did not change Ruminococcus gauvreauii growth in culture.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2c93cdc2-0a4f-5b9a-9921-3af6a6fdf2e4","mechanism_event_label":"Naringenin severely inhibited Enterococcus caccae, slightly enhanced Bifidobacterium catenulatum, and did not change Ruminococcus gauvreauii growth in culture.","subject":{"id":"2a9350f6-01cc-5bea-8213-cd3ebb1b05cf","slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"},"object":{"id":"dae25c38-4be0-5cda-a2aa-ec2b8cebb87a","slug":"selected-human-commensal-growth","display_name":"Growth of selected human gut commensals","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2c93cdc2-0a4f-5b9a-9921-3af6a6fdf2e4","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-microbial-growth-selectivity-event","event_type":"observed_relationship","label":"Naringenin severely inhibited Enterococcus caccae, slightly enhanced Bifidobacterium catenulatum, and did not change Ruminococcus gauvreauii growth in culture.","description":"Naringenin severely inhibited Enterococcus caccae, slightly enhanced Bifidobacterium catenulatum, and did not change Ruminococcus gauvreauii growth in culture.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2a9350f6-01cc-5bea-8213-cd3ebb1b05cf","slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dae25c38-4be0-5cda-a2aa-ec2b8cebb87a","slug":"selected-human-commensal-growth","display_name":"Growth of selected human gut commensals","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Naringenin exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Time-course culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three cultured human commensal bacterial species","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Three isolated species do not represent community-level or in-vivo microbiome effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Naringenin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Three cultured human commensal bacterial species","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Naringenin severely inhibited Enterococcus caccae, slightly enhanced Bifidobacterium catenulatum, and did not change Ruminococcus gauvreauii growth in culture.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Analysis of Temporal Changes in Growth and Gene Expression for Commensal Gut Microbes in Response to the Polyphenol Naringenin. (2018). https://pubmed.ncbi.nlm.nih.gov/30013359/ DOI: 10.1177/1178636118775100","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro microbial culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Growth curves and single-molecule RNA sequencing","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"385fcfb9-2793-5d74-86c2-02da07f6a3c3","evidence_kind":"source_excerpt","locator":"Lines 110-119","start_line":110,"end_line":119,"excerpt":"## naringenin-microbial-growth-selectivity\nNaringenin severely inhibited Enterococcus caccae, slightly enhanced Bifidobacterium catenulatum, and did not change Ruminococcus gauvreauii growth in culture.\nModel/species: Three cultured human commensal bacterial species\nTissue/system: Growth curves and single-molecule RNA sequencing\nExposure: Naringenin exposure\nRoute: In vitro microbial culture\nDuration: Time-course culture\nLimits: Three isolated species do not represent community-level or in-vivo microbiome effects.\nPrimary reference: Analysis of Temporal Changes in Growth and Gene Expression for Commensal Gut Microbes in Response to the Polyphenol Naringenin. (2018). https://pubmed.ncbi.nlm.nih.gov/30013359/ DOI: 10.1177/1178636118775100\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Three cultured human commensal bacterial species","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2804932d-46eb-5c43-8a45-0505e6b1ee05","stable_key":"import-d2e91bc7-8177-5ad3-ad9b-5d65813ce082","title":"Naringenin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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