{"id":"20c452bf-3a76-5e3d-9d3c-a8086138948f","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-signaling","predicate":"associated_with_basal_signal_changes","statement":"After vanadyl treatment, muscle showed trends toward increased basal insulin-receptor, IRS1 and Shc tyrosine phosphorylation and IRS1-associated PI3K activity without additional insulin-stimulated increases.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cf5c7d8b-3839-5cd2-902e-55ba1857e4c5","mechanism_event_label":"Early signaling markers did not guarantee a larger response to insulin.","subject":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"object":{"id":"5cd18880-8dc7-5897-9362-7422684f5f79","slug":"insr","display_name":"Insulin receptor / INSR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"cf5c7d8b-3839-5cd2-902e-55ba1857e4c5","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-signaling-event","event_type":"observed_relationship","label":"Early signaling markers did not guarantee a larger response to insulin.","description":"After vanadyl treatment, muscle showed trends toward increased basal insulin-receptor, IRS1 and Shc tyrosine phosphorylation and IRS1-associated PI3K activity without additional insulin-stimulated increases.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5cd18880-8dc7-5897-9362-7422684f5f79","slug":"insr","display_name":"Insulin receptor / INSR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1d558783-9f80-531e-b09f-4c69e08ac426","slug":"irs1","display_name":"Human insulin receptor substrate 1 / IRS1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"208dee08-9cc5-5a66-85af-7fe06dec6e4f","slug":"shc1","display_name":"Human SHC1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human muscle samples from the same 16-person trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reported as trends; phosphorylation patterns did not clearly correlate with glucose disposal. No proven nutrient requirement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Early signaling markers did not guarantee a larger response to insulin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8fc1f503-2da0-556b-b9b4-f4c1517a22e4","evidence_kind":"source_excerpt","locator":"Lines 390-396","start_line":390,"end_line":396,"excerpt":"## vanadium-human-signaling\nEarly signaling markers did not guarantee a larger response to insulin.\nAfter vanadyl treatment, muscle showed trends toward increased basal insulin-receptor, IRS1 and Shc tyrosine phosphorylation and IRS1-associated PI3K activity without additional insulin-stimulated increases.\nModel: Human muscle samples from the same 16-person trial.\nLimitations: Reported as trends; phosphorylation patterns did not clearly correlate with glucose disposal. No proven nutrient requirement.\nEvidence access: Primary abstract\nMetabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9","model_system":"Human muscle samples from the same 16-person trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"d36b30d972e756ca4d19b66f976980e206c65025bd4bbf4c127c17320bd019c2","revision_id":"70d42967-8032-5627-8670-f59841735e89","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}