{"id":"208781dc-3478-5e38-8db0-30b04bfefdaa","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-phase2-null","predicate":"does_not_significantly_induce","statement":"Hydroxytyrosol at 5 or 25 mg/day for one week did not significantly change PBMC phase-II enzyme expression in a randomized placebo-controlled Latin-square study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"f8b5af65-bef6-58d0-8802-a991171e152c","mechanism_event_label":"Hydroxytyrosol at 5 or 25 mg/day for one week did not significantly change PBMC phase-II enzyme expression in a randomized placebo-controlled Latin-square study.","subject":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"object":{"id":"bc613c36-9ff1-5d76-bd16-28dba7812ebe","slug":"human-pbmc-phase2-enzyme-expression","display_name":"Phase-II enzyme expression in human PBMCs","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f8b5af65-bef6-58d0-8802-a991171e152c","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-phase2-null-event","event_type":"observed_relationship","label":"Hydroxytyrosol at 5 or 25 mg/day for one week did not significantly change PBMC phase-II enzyme expression in a randomized placebo-controlled Latin-square study.","description":"Hydroxytyrosol at 5 or 25 mg/day for one week did not significantly change PBMC phase-II enzyme expression in a randomized placebo-controlled Latin-square study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bc613c36-9ff1-5d76-bd16-28dba7812ebe","slug":"human-pbmc-phase2-enzyme-expression","display_name":"Phase-II enzyme expression in human PBMCs","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"5 or 25 mg/day hydroxytyrosol versus placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"1 week","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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