{"id":"2070f00e-f3b3-552e-8fd1-0ef4951999e3","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taut-guanidinoacetate","predicate":"binds","statement":"The human TauT study captured guanidinoacetate-bound transporter structures as part of its substrate-recognition analysis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ae4c1fda-5ec5-5f4e-95f2-6313f8cae648","mechanism_event_label":"A creatine precursor also connects to this transporter.","subject":{"id":"84053a83-8fcc-5068-8df9-58f7e97fad76","slug":"guanidinoacetate","display_name":"Guanidinoacetate","entity_type_key":"small_molecule"},"object":{"id":"c00b89ac-1c32-5d7d-aec4-490af879460a","slug":"slc6a6","display_name":"Human taurine transporter / SLC6A6","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"ae4c1fda-5ec5-5f4e-95f2-6313f8cae648","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taut-guanidinoacetate-event","event_type":"observed_relationship","label":"A creatine precursor also connects to this transporter.","description":"The human TauT study captured guanidinoacetate-bound transporter structures as part of its substrate-recognition analysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"84053a83-8fcc-5068-8df9-58f7e97fad76","slug":"guanidinoacetate","display_name":"Guanidinoacetate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c00b89ac-1c32-5d7d-aec4-490af879460a","slug":"slc6a6","display_name":"Human taurine transporter / SLC6A6","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human SLC6A6 structural study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Binding structures alone do not quantify net transport or competition in a living human.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A creatine precursor also connects to this transporter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Molecular basis of human taurine transporter uptake and inhibition. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40789850/ · DOI 10.1038/s41467-025-62857-w","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d4eff6d2-91ff-5a16-8bd7-eab630a95257","evidence_kind":"source_excerpt","locator":"Lines 137-143","start_line":137,"end_line":143,"excerpt":"## taurine-taut-guanidinoacetate\nA creatine precursor also connects to this transporter.\nThe human TauT study captured guanidinoacetate-bound transporter structures as part of its substrate-recognition analysis.\nModel: Human SLC6A6 structural study.\nLimitations: Binding structures alone do not quantify net transport or competition in a living human.\nEvidence access: Primary abstract\nMolecular basis of human taurine transporter uptake and inhibition. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40789850/ · DOI 10.1038/s41467-025-62857-w","model_system":"Human SLC6A6 structural study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}