{"id":"1f707ce1-d98e-5632-a408-1ed2748e6403","stable_key":"availability:selenium-sperm-gpx4:1","predicate":"can_impair","statement":"Selenium restriction can impair male fertility in animal models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"source_reported: Strong genetic and animal-model evidence as reported by the supplied reference; unverified source synthesis.","direction":"negative","is_public":true,"mechanism_event_id":"9c8ac6cc-6bfd-5af2-9389-f92161036aaf","mechanism_event_label":"Selenium restriction can impair male fertility in animal models.","subject":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"object":{"id":"8ddf3af8-d323-5d24-8808-3ddf39e6cf76","slug":"male-fertility","display_name":"Male fertility","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9c8ac6cc-6bfd-5af2-9389-f92161036aaf","stable_key":"availability:selenium-sperm-gpx4:1","event_type":"availability_dependent_change","label":"Selenium restriction can impair male fertility in animal models.","description":"Selenium restriction affects sperm biology; genetic disruption of delivery or GPX4 provides related but distinct evidence. Animal dietary-restriction and genetic models; the experiments address related mechanisms with different perturbations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"condition_input","stoichiometry":null,"state_label":"Selenium restriction affects sperm biology; genetic disruption of delivery or GPX4 provides related but distinct evidence.","sequence_order":0,"notes":""},{"entity":{"id":"8ddf3af8-d323-5d24-8808-3ddf39e6cf76","slug":"male-fertility","display_name":"Male fertility","entity_type_key":"cellular_process"},"role":"affected_component","stoichiometry":null,"state_label":"Selenium restriction affects sperm biology; genetic disruption of delivery or GPX4 provides related but distinct evidence.","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"Selenium restriction affects sperm biology; genetic disruption of delivery or GPX4 provides related but distinct evidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_scope","value_text":"Animal dietary-restriction and genetic models; the experiments address related mechanisms with different perturbations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genetic loss is not an ordinary dietary-deficiency phenotype. No human plasma threshold or guaranteed fertility outcome is established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f9640879-fe38-5604-85f8-57ea08bbbe9b","evidence_kind":"source_passage","locator":"lines 420-430","start_line":420,"end_line":430,"excerpt":"4.5 Male fertility\n\nGPX4 has a distinctive role in sperm: during maturation, a structural form contributes to the mitochondrial sheath. Selenium restriction and disruption of the SELENOP–ApoER2/LRP8 pathway can impair male fertility in animal models.\n\nSELENOP delivery / GPX4 biology disrupted\n        ↓\nmitochondrial-sheath and membrane defects\n        ↓\nreduced sperm motility and fertility in experimental models\n\nEvidence: strong genetic and animal-model evidence; translation to a specific human plasma selenium threshold is not established.","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}}],"relations":[],"conflicts":[],"corrections":[],"research":null}