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Intolerance is self-evidently multifactorial, and the proposed intestinal-concentration mechanism was not measured here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"metformin","display_name":"Metformin","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The transporter that controls where the drug goes is also linked to who cannot tolerate it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[metformin-p25510240] Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. 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Intolerance is self-evidently multifactorial, and the proposed intestinal-concentration mechanism was not measured here.\nexposure: Prescribed metformin, OCT1 genotype and co-prescribed OCT1 inhibitors\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/25510240.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f8eaf94237679ed7436f863e210d17b13a7219d064e46e7da915ed083c5b04c9\", \"start_char\": 0, \"end_char\": 1355, \"text_sha256\": \"f8eaf94237679ed7436f863e210d17b13a7219d064e46e7da915ed083c5b04c9\"}\n[metformin-p25510240] Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. 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