{"id":"1ecf9822-dd89-55fc-bd05-5d0937711680","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-infant-retinol-null","predicate":"does_not_significantly_change","statement":"In a six-week pilot feeding study, Moringa-fortified complementary foods produced only marginal, nonsignificant blood-retinol increases, and all infants remained vitamin A deficient.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"1ceed738-fc1f-5405-8af6-e43e31911487","mechanism_event_label":"In a six-week pilot feeding study, Moringa-fortified complementary foods produced only marginal, nonsignificant blood-retinol increases, and all infants remained vitamin A deficient.","subject":{"id":"be7e2664-cc62-5614-b491-dbba6ca516bf","slug":"moringa-fortified-infant-food","display_name":"Complementary infant foods fortified with Moringa leaf powder","entity_type_key":"botanical"},"object":{"id":"e0836045-9dfb-5858-b35d-757874336281","slug":"infant-blood-retinol-concentration","display_name":"Blood retinol concentration in vitamin-A-deficient infants","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1ceed738-fc1f-5405-8af6-e43e31911487","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-infant-retinol-null-event","event_type":"observed_relationship","label":"In a six-week pilot feeding study, Moringa-fortified complementary foods produced only marginal, nonsignificant blood-retinol increases, and all infants remained vitamin A deficient.","description":"In a six-week pilot feeding study, Moringa-fortified complementary foods produced only marginal, nonsignificant blood-retinol increases, and all infants remained vitamin A deficient.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"be7e2664-cc62-5614-b491-dbba6ca516bf","slug":"moringa-fortified-infant-food","display_name":"Complementary infant foods fortified with Moringa leaf powder","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e0836045-9dfb-5858-b35d-757874336281","slug":"infant-blood-retinol-concentration","display_name":"Blood retinol concentration in vitamin-A-deficient infants","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Two Moringa-fortified foods versus a cereal-legume control","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Six weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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(2018). https://pubmed.ncbi.nlm.nih.gov/29962920/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral feeding","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Whole-blood retinol","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d56f392c-a585-5e6e-9ded-dee076c4e67d","evidence_kind":"source_excerpt","locator":"Lines 244-253","start_line":244,"end_line":253,"excerpt":"## moringa-infant-retinol-null\nIn a six-week pilot feeding study, Moringa-fortified complementary foods produced only marginal, nonsignificant blood-retinol increases, and all infants remained vitamin A deficient.\nModel/species: Sixty-five completing infant-mother pairs in Ghana\nTissue/system: Whole-blood retinol\nExposure: Two Moringa-fortified foods versus a cereal-legume control\nRoute: Oral feeding\nDuration: Six weeks\nLimits: The pilot had substantial attrition and short follow-up; its null result does not contradict measured carotenoid conversion in well-nourished children.\nPrimary reference: Improving Blood Retinol Concentrations with Complementary Foods Fortified with Moringa oleifera Leaf Powder - A Pilot Study. 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