{"id":"1e841ac0-0540-5a47-ab91-e1de3ba67372","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-hpp-high-plasma-plp","predicate":"deficiency_associated_with_high_circulating_plp","statement":"All 14 hypophosphatasia patients had elevated plasma PLP; the mean was 1174 nM versus 57 nM in controls.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4a62588a-291d-566f-b625-4d7e94422db3","mechanism_event_label":"A high B6-related blood measurement can reflect faulty processing rather than extra intake.","subject":{"id":"3148c377-9b4c-56ca-bc36-081bf1905d57","slug":"alpl","display_name":"Tissue-nonspecific alkaline phosphatase ALPL / TNAP","entity_type_key":"protein"},"object":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4a62588a-291d-566f-b625-4d7e94422db3","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-hpp-high-plasma-plp-event","event_type":"observed_intervention","label":"A high B6-related blood measurement can reflect faulty processing rather than extra intake.","description":"All 14 hypophosphatasia patients had elevated plasma PLP; the mean was 1174 nM versus 57 nM in controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"measured_vitamer","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3148c377-9b4c-56ca-bc36-081bf1905d57","slug":"alpl","display_name":"Tissue-nonspecific alkaline phosphatase ALPL / TNAP","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"ALPL links mineralization biology with B6 handling; this result alone does not imply calcium causes B6 deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fourteen hypophosphatasia patients compared with 38 controls; urinary catabolite studied in four affected children.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Endogenous ALPL enzyme deficiency; ordinary dietary B6 in urinary subset.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small heterogeneous disease cohort; concentrations are not diagnostic thresholds for general nutrition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A high B6-related blood measurement can reflect faulty processing rather than extra intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-whyte1985] Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism (1985). https://pubmed.ncbi.nlm.nih.gov/4031070/ DOI: 10.1172/jci112031","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood and whole-body measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"fb98a49d-65bb-549b-9360-057b292d7d42","evidence_kind":"source_excerpt","locator":"Lines 1608-1619","start_line":1608,"end_line":1619,"excerpt":"### b6-hpp-high-plasma-plp\nAll 14 hypophosphatasia patients had elevated plasma PLP; the mean was 1174 nM versus 57 nM in controls.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A high B6-related blood measurement can reflect faulty processing rather than extra intake.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood and whole-body measurements\nexperimental_model: Fourteen hypophosphatasia patients compared with 38 controls; urinary catabolite studied in four affected children.\nlimitations: Small heterogeneous disease cohort; concentrations are not diagnostic thresholds for general nutrition.\nexposure: Endogenous ALPL enzyme deficiency; ordinary dietary B6 in urinary subset.\ncross_nutrient: ALPL links mineralization biology with B6 handling; this result alone does not imply calcium causes B6 deficiency.\n[b6-whyte1985] Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism (1985). https://pubmed.ncbi.nlm.nih.gov/4031070/ DOI: 10.1172/jci112031","model_system":"Fourteen hypophosphatasia patients compared with 38 controls; urinary catabolite studied in four affected children.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-whyte1985] Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism (1985). https://pubmed.ncbi.nlm.nih.gov/4031070/ DOI: 10.1172/jci112031","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}