{"id":"1e584110-7da3-5e9e-9939-c2eba7c2c3d3","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-hepatic-lipids","predicate":"reduces","statement":"Astaxanthin reduced lipid accumulation and altered lipid-metabolism transcripts in lipid-loaded HepG2 cells; transcriptomics used 100 micromolar exposure.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"007e7fda-a0f6-5e5d-87ff-172abc9ef848","mechanism_event_label":"High-concentration treatment changed lipid storage in cultured liver cells.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"724f3ce2-9475-599f-8a1c-22f6e2632250","slug":"human-hepatic-astaxanthin-lipid-storage","display_name":"Lipid accumulation after astaxanthin in human HepG2 cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"007e7fda-a0f6-5e5d-87ff-172abc9ef848","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-hepatic-lipids-event","event_type":"observed_relationship","label":"High-concentration treatment changed lipid storage in cultured liver cells.","description":"Astaxanthin reduced lipid accumulation and altered lipid-metabolism transcripts in lipid-loaded HepG2 cells; transcriptomics used 100 micromolar exposure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"724f3ce2-9475-599f-8a1c-22f6e2632250","slug":"human-hepatic-astaxanthin-lipid-storage","display_name":"Lipid accumulation after astaxanthin in human HepG2 cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text, HepG2 experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human hepatoma-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This exposure and cancer-derived model do not establish a treatment effect in human fatty liver.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"High-concentration treatment changed lipid storage in cultured liver cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22707263/ · DOI 10.1002/mnfr.201100798","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e1741db4-aeed-5d6c-95d4-1276554d87b3","evidence_kind":"source_excerpt","locator":"Lines 262-268","start_line":262,"end_line":268,"excerpt":"## astaxanthin-hepatic-lipids\nHigh-concentration treatment changed lipid storage in cultured liver cells.\nAstaxanthin reduced lipid accumulation and altered lipid-metabolism transcripts in lipid-loaded HepG2 cells; transcriptomics used 100 micromolar exposure.\nModel: Human hepatoma-cell experiments.\nLimitations: This exposure and cancer-derived model do not establish a treatment effect in human fatty liver.\nEvidence access: Primary full text, HepG2 experiments\nThe natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22707263/ · DOI 10.1002/mnfr.201100798","model_system":"Human hepatoma-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}