{"id":"1e4b89d4-4e7f-52bf-aa03-99753d0b423c","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-gpvi-binding","predicate":"binds","statement":"SPR supported luteolin binding to human GPVI, and a solid-phase assay showed reduced collagen–GPVI interaction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cd9df955-5c01-5b24-9f06-08c597211ac9","mechanism_event_label":"A platelet collagen receptor is a measured binding target.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"d272a278-9216-5556-a41c-56fbb2cf3e8f","slug":"gp6","display_name":"Human platelet glycoprotein VI / GP6","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"cd9df955-5c01-5b24-9f06-08c597211ac9","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-gpvi-binding-event","event_type":"observed_relationship","label":"A platelet collagen receptor is a measured binding target.","description":"SPR supported luteolin binding to human GPVI, and a solid-phase assay showed reduced collagen–GPVI interaction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d272a278-9216-5556-a41c-56fbb2cf3e8f","slug":"gp6","display_name":"Human platelet glycoprotein VI / GP6","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human GPVI binding assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Binding-site mutations and crystal confirmation were not provided.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A platelet collagen receptor is a measured binding target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis. · 2023 · https://pubmed.ncbi.nlm.nih.gov/38026984/ · DOI 10.3389/fphar.2023.1255069","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"067c55fd-be9a-538e-93eb-7c36dcc370a1","evidence_kind":"source_excerpt","locator":"Lines 428-434","start_line":428,"end_line":434,"excerpt":"## luteolin-gpvi-binding\nA platelet collagen receptor is a measured binding target.\nSPR supported luteolin binding to human GPVI, and a solid-phase assay showed reduced collagen–GPVI interaction.\nModel: Human GPVI binding assays.\nLimitations: Binding-site mutations and crystal confirmation were not provided.\nEvidence access: Primary full text\nLuteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis. · 2023 · https://pubmed.ncbi.nlm.nih.gov/38026984/ · DOI 10.3389/fphar.2023.1255069","model_system":"Human GPVI binding assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}