{"id":"1da40773-b29f-5bce-9c15-a722c1463968","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-ign-camp","predicate":"modulates","statement":"Butyrate activated intestinal gluconeogenic gene expression through a cAMP-dependent mechanism in the rodent study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"77579b1b-aa93-5a8f-9b11-d53aa242b1c2","mechanism_event_label":"A gut glucose-producing pathway contributed to metabolic signaling.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"b452997c-9762-56bd-97aa-a73d7bf47fcb","slug":"rodent-butyrate-intestinal-gluconeogenesis","display_name":"Rodent intestinal gluconeogenic response to butyrate; species unresolved in accessed abstract","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"77579b1b-aa93-5a8f-9b11-d53aa242b1c2","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-ign-camp-event","event_type":"observed_relationship","label":"A gut glucose-producing pathway contributed to metabolic signaling.","description":"Butyrate activated intestinal gluconeogenic gene expression through a cAMP-dependent mechanism in the rodent study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b452997c-9762-56bd-97aa-a73d7bf47fcb","slug":"rodent-butyrate-intestinal-gluconeogenesis","display_name":"Rodent intestinal gluconeogenic response to butyrate; species unresolved in accessed abstract","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rodent intestinal metabolism and signaling experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The paper assigned propionate, not butyrate, the distinct FFAR3-dependent gut-brain route; butyrate is not being labeled a net glucose carbon source.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A gut glucose-producing pathway contributed to metabolic signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24412651/ · DOI 10.1016/j.cell.2013.12.016","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dd10fcd4-df3c-50c0-934e-2468de8e03c6","evidence_kind":"source_excerpt","locator":"Lines 518-524","start_line":518,"end_line":524,"excerpt":"## butyrate-ign-camp\nA gut glucose-producing pathway contributed to metabolic signaling.\nButyrate activated intestinal gluconeogenic gene expression through a cAMP-dependent mechanism in the rodent study.\nModel: Rodent intestinal metabolism and signaling experiments.\nLimitations: The paper assigned propionate, not butyrate, the distinct FFAR3-dependent gut-brain route; butyrate is not being labeled a net glucose carbon source.\nEvidence access: Primary abstract\nMicrobiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24412651/ · DOI 10.1016/j.cell.2013.12.016","model_system":"Rodent intestinal metabolism and signaling experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}