{"id":"1d8a0851-d458-52f9-abdc-e03543379204","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-procynz-glucose","predicate":"is_associated_with_reduction","statement":"The 15-person uncontrolled pilot reported lower fasting glucose after procynZ-45 exposure.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5708f87f-4a15-5281-a041-88031d6dc102","mechanism_event_label":"Glucose fell during a small pilot, but without a control group the extract’s causal effect is uncertain.","subject":{"id":"42764814-0204-5724-8d7a-ebba9a146d40","slug":"ceylon-procynz45","display_name":"C. zeylanicum procynZ-45 polyphenol extract","entity_type_key":"chemical_species"},"object":{"id":"e4efb34e-ff1b-5f72-aacc-601c0e6ebafa","slug":"serum-glucose-concentration","display_name":"Serum glucose concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5708f87f-4a15-5281-a041-88031d6dc102","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-procynz-glucose-event","event_type":"observed_intervention","label":"Glucose fell during a small pilot, but without a control group the extract’s causal effect is uncertain.","description":"The 15-person uncontrolled pilot reported lower fasting glucose after procynZ-45 exposure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"42764814-0204-5724-8d7a-ebba9a146d40","slug":"ceylon-procynz45","display_name":"C. zeylanicum procynZ-45 polyphenol extract","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e4efb34e-ff1b-5f72-aacc-601c0e6ebafa","slug":"serum-glucose-concentration","display_name":"Serum glucose concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/25051315.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3a6dc6fe3a75793687a15c6ce73ab8ae07dbf8541c5b329d2f35c1a42922d5bb\", \"start_char\": 0, \"end_char\": 1406, \"text_sha256\": \"3a6dc6fe3a75793687a15c6ce73ab8ae07dbf8541c5b329d2f35c1a42922d5bb\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Extract comparison in diabetic rats plus uncontrolled human pilot","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Rats 200 mg/kg for 30 days; 15 unmedicated adults, procynZ-45 125 mg twice daily for 30 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"GAE denotes assay standardization, not proof that 45% of extract mass is a single polyphenol. Human pilot lacked a randomized control.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Glucose fell during a small pilot, but without a control group the extract’s causal effect is uncertain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p25051315] Effects of the polyphenol content on the anti-diabetic activity of Cinnamomum zeylanicum extracts. (2014). https://pubmed.ncbi.nlm.nih.gov/25051315/ DOI: 10.1039/c4fo00130c","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Metabolic measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0dcc4acf-d90d-57b7-80e9-12f24e5c1167","evidence_kind":"source_excerpt","locator":"Lines 1091-1102","start_line":1091,"end_line":1102,"excerpt":"### ceylon-procynz-glucose\nThe 15-person uncontrolled pilot reported lower fasting glucose after procynZ-45 exposure.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Glucose fell during a small pilot, but without a control group the extract’s causal effect is uncertain.\norganism: Human\ntissue_or_cell_type: Metabolic measurements\nexperimental_model: Extract comparison in diabetic rats plus uncontrolled human pilot\nlimitations: GAE denotes assay standardization, not proof that 45% of extract mass is a single polyphenol. Human pilot lacked a randomized control.\nexposure: Rats 200 mg/kg for 30 days; 15 unmedicated adults, procynZ-45 125 mg twice daily for 30 days\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/25051315.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3a6dc6fe3a75793687a15c6ce73ab8ae07dbf8541c5b329d2f35c1a42922d5bb\", \"start_char\": 0, \"end_char\": 1406, \"text_sha256\": \"3a6dc6fe3a75793687a15c6ce73ab8ae07dbf8541c5b329d2f35c1a42922d5bb\"}\n[ceylon-p25051315] Effects of the polyphenol content on the anti-diabetic activity of Cinnamomum zeylanicum extracts. (2014). https://pubmed.ncbi.nlm.nih.gov/25051315/ DOI: 10.1039/c4fo00130c","model_system":"Extract comparison in diabetic rats plus uncontrolled human pilot","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p25051315] Effects of the polyphenol content on the anti-diabetic activity of Cinnamomum zeylanicum extracts. (2014). https://pubmed.ncbi.nlm.nih.gov/25051315/ DOI: 10.1039/c4fo00130c","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3aed3c5b-8016-5e37-ad6f-9019d34d19eb","stable_key":"import-3d41d18a-e13a-59a0-a081-55bfcdd43e55","title":"Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"639b1d8dcff42f2cf1f00a7dc38202289b70213e37c357c375b1f5905d6cf832","revision_id":"9675eb03-ee34-5160-b928-46b6ca9d1ecc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}