{"id":"1d720e4f-1f94-5494-9ab6-2bd0aae99025","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-lps-synthesis","predicate":"impairs","statement":"Acute LPS inflammatory stress reduced NAD+ by impairing synthesis in both young and aged mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e4f85958-6e7a-5668-80f3-c3c6ffaaf324","mechanism_event_label":"Acute inflammation can impair supply through a different pattern from ordinary aging.","subject":{"id":"ee54624f-0782-567b-ae0c-c563c05a9563","slug":"mouse-lps-inflammatory-stress","display_name":"Acute LPS inflammatory stress in mice","entity_type_key":"cellular_process"},"object":{"id":"52cea63d-da4a-517b-a5b0-ac5b9cca2b29","slug":"mouse-absolute-nad-biosynthesis","display_name":"Absolute NAD biosynthetic flux in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e4f85958-6e7a-5668-80f3-c3c6ffaaf324","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-lps-synthesis-event","event_type":"observed_relationship","label":"Acute inflammation can impair supply through a different pattern from ordinary aging.","description":"Acute LPS inflammatory stress reduced NAD+ by impairing synthesis in both young and aged mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ee54624f-0782-567b-ae0c-c563c05a9563","slug":"mouse-lps-inflammatory-stress","display_name":"Acute LPS inflammatory stress in mice","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"52cea63d-da4a-517b-a5b0-ac5b9cca2b29","slug":"mouse-absolute-nad-biosynthesis","display_name":"Absolute NAD biosynthetic flux in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse isotope-tracing intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"LPS challenge is not equivalent to every chronic inflammatory condition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"NAD+ collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Acute inflammation can impair supply through a different pattern from ordinary aging.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"NAD+ flux is maintained in aged mice despite lower tissue concentrations. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34559996/ · DOI 10.1016/j.cels.2021.09.001","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e62f682c-305a-57df-835e-5a72ce07f487","evidence_kind":"source_excerpt","locator":"Lines 140-146","start_line":140,"end_line":146,"excerpt":"## nad-plus-lps-synthesis\nAcute inflammation can impair supply through a different pattern from ordinary aging.\nAcute LPS inflammatory stress reduced NAD+ by impairing synthesis in both young and aged mice.\nModel: Mouse isotope-tracing intervention.\nLimitations: LPS challenge is not equivalent to every chronic inflammatory condition.\nEvidence access: Primary full text\nNAD+ flux is maintained in aged mice despite lower tissue concentrations. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34559996/ · DOI 10.1016/j.cels.2021.09.001","model_system":"Mouse isotope-tracing intervention.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f59aa302-d463-5462-876f-e21e64861eac","stable_key":"import-8c946991-97f0-55ee-8df0-00e67621962f","title":"NAD+: compartmental supply, consumption and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"9f5324d0d652c80ad630b3100e28ce34cd2ce260ea2e1324332a4262ce72ae09","revision_id":"0e07909c-e8bc-5950-bafc-61371d9d6412","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}