{"id":"1d681f6e-06c5-5b3e-8128-f675b3166f02","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-macrophage-cd36","predicate":"increases_expression","statement":"Astaxanthin increased Cd36 and Abca1 transcripts in elicited mouse peritoneal macrophages, despite different effects on the adipocyte program.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6e4126f1-453c-53ff-aea7-72202e146bc8","mechanism_event_label":"The same treatment produced a different gene response in immune cells.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"98f1fe60-4f89-5d3f-830a-d1f61988a90c","slug":"mouse-cd36","display_name":"Mouse fatty-acid translocase / Cd36","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"6e4126f1-453c-53ff-aea7-72202e146bc8","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-macrophage-cd36-event","event_type":"observed_relationship","label":"The same treatment produced a different gene response in immune cells.","description":"Astaxanthin increased Cd36 and Abca1 transcripts in elicited mouse peritoneal macrophages, despite different effects on the adipocyte program.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"98f1fe60-4f89-5d3f-830a-d1f61988a90c","slug":"mouse-cd36","display_name":"Mouse fatty-acid translocase / Cd36","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse macrophage expression assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression does not measure net cholesterol clearance or prove clinical antiatherosclerotic efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same treatment produced a different gene response in immune cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22732454/ · DOI 10.1016/j.bcp.2012.05.021","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a49ba927-e253-5b34-84d7-3c7fcd4c3b42","evidence_kind":"source_excerpt","locator":"Lines 286-292","start_line":286,"end_line":292,"excerpt":"## astaxanthin-macrophage-cd36\nThe same treatment produced a different gene response in immune cells.\nAstaxanthin increased Cd36 and Abca1 transcripts in elicited mouse peritoneal macrophages, despite different effects on the adipocyte program.\nModel: Mouse macrophage expression assays.\nLimitations: Expression does not measure net cholesterol clearance or prove clinical antiatherosclerotic efficacy.\nEvidence access: Primary abstract\nAstaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22732454/ · DOI 10.1016/j.bcp.2012.05.021","model_system":"Mouse macrophage expression assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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