{"id":"1d562ed9-dd6f-59cf-af40-ea60760f4ab0","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-allopurinol-bp","predicate":"attenuates_fructose_response","statement":"Allopurinol prevented the fructose-associated increase in 24-hour diastolic and daytime systolic/diastolic blood pressure.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4881e804-8dea-53e2-a463-981b4af6323e","mechanism_event_label":"Allopurinol prevented the fructose-associated increase in 24-hour diastolic and daytime systolic/diastolic blood pressure.","subject":{"id":"cfa51e26-3627-5a5e-9270-89c53f9db01b","slug":"allopurinol","display_name":"Allopurinol","entity_type_key":"small_molecule"},"object":{"id":"1ab17e53-cf58-5ff0-b485-fc604ac7fb49","slug":"human-fructose-loading-ambulatory-bp","display_name":"Human ambulatory blood pressure during experimental fructose loading","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4881e804-8dea-53e2-a463-981b4af6323e","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-allopurinol-bp-event","event_type":"observed_relationship","label":"Allopurinol prevented the fructose-associated increase in 24-hour diastolic and daytime systolic/diastolic blood pressure.","description":"Allopurinol prevented the fructose-associated increase in 24-hour diastolic and daytime systolic/diastolic blood pressure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cfa51e26-3627-5a5e-9270-89c53f9db01b","slug":"allopurinol","display_name":"Allopurinol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1ab17e53-cf58-5ff0-b485-fc604ac7fb49","slug":"human-fructose-loading-ambulatory-bp","display_name":"Human ambulatory blood pressure during experimental fructose loading","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3c379840-5688-5b5d-84c0-5950b4fd8f17","slug":"fructose","display_name":"Fructose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8b3659b4-1c0e-57f1-ae60-c9300b21359d","slug":"urate","display_name":"Urate / uric acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"200 g fructose/day with or without allopurinol; drug dose not recovered in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"2 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"74 adult men in randomized fructose-loading intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Isolated fructose / drug perturbation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Very high pure-fructose dose; allopurinol did not correct every outcome. Pharmacological rescue does not prove sole mediation by urate or justify treatment of ordinary HFCS intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"74 adult men in randomized fructose-loading intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Allopurinol prevented the fructose-associated increase in 24-hour diastolic and daytime systolic/diastolic blood pressure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. (2010). https://pubmed.ncbi.nlm.nih.gov/20029377/ DOI: 10.1038/ijo.2009.259","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral fructose and oral drug","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Urate, ambulatory blood pressure and metabolic markers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"27aee075-7b2b-53bd-8647-14f2e3ed57cc","evidence_kind":"source_excerpt","locator":"Lines 545-555","start_line":545,"end_line":555,"excerpt":"## hfcs-allopurinol-bp\nAllopurinol prevented the fructose-associated increase in 24-hour diastolic and daytime systolic/diastolic blood pressure.\nModel/species: 74 adult men in randomized fructose-loading intervention\nTissue: Urate, ambulatory blood pressure and metabolic markers\nExposure: 200 g fructose/day with or without allopurinol; drug dose not recovered in accessed abstract\nRoute: Oral fructose and oral drug\nDuration: 2 weeks\nExposure scope: Isolated fructose / drug perturbation\nLimits: Very high pure-fructose dose; allopurinol did not correct every outcome. Pharmacological rescue does not prove sole mediation by urate or justify treatment of ordinary HFCS intake.\nReference: Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. (2010). https://pubmed.ncbi.nlm.nih.gov/20029377/ DOI: 10.1038/ijo.2009.259\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"74 adult men in randomized fructose-loading intervention","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"f4721923a83b368d549ba110a4f8c8738026210b32f6d29f3bd3200aa420f3b3","revision_id":"45827d73-cb6d-5aff-969b-af364b74b168","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}