{"id":"1cb4c508-a395-5c59-9c65-0fd3f83845f9","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-potassium-excretion","predicate":"dose_dependently_increases","statement":"Potassium excretion increased after 600 mg lithium carbonate but not after 300 mg in the volunteer study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bee60cb2-5dde-504d-95a4-5e2da4dc60d0","mechanism_event_label":"The potassium response depended on exposure.","subject":{"id":"bb5db13c-d287-5847-93b2-98ab0d023797","slug":"lithium-carbonate","display_name":"Lithium carbonate","entity_type_key":"small_molecule"},"object":{"id":"287cefe2-c69e-52f6-bbb4-fa22e8a19011","slug":"human-urinary-potassium-excretion","display_name":"Human urinary potassium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bee60cb2-5dde-504d-95a4-5e2da4dc60d0","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-potassium-excretion-event","event_type":"observed_relationship","label":"The potassium response depended on exposure.","description":"Potassium excretion increased after 600 mg lithium carbonate but not after 300 mg in the volunteer study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bb5db13c-d287-5847-93b2-98ab0d023797","slug":"lithium-carbonate","display_name":"Lithium carbonate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"287cefe2-c69e-52f6-bbb4-fa22e8a19011","slug":"human-urinary-potassium-excretion","display_name":"Human urinary potassium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"15 healthy adults; about 19 mmol extra potassium over 24 hours at the higher dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that every lithium user develops potassium depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The potassium response depended on exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of a single test dose of lithium carbonate on sodium and potassium excretion in man. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1649725/ · DOI 10.1042/cs0810059","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fe03da69-e7a1-59df-88cf-00bad70f8abc","evidence_kind":"source_excerpt","locator":"Lines 360-366","start_line":360,"end_line":366,"excerpt":"## lithium-potassium-excretion\nThe potassium response depended on exposure.\nPotassium excretion increased after 600 mg lithium carbonate but not after 300 mg in the volunteer study.\nModel: 15 healthy adults; about 19 mmol extra potassium over 24 hours at the higher dose.\nLimitations: Not evidence that every lithium user develops potassium depletion.\nEvidence access: Primary abstract\nEffect of a single test dose of lithium carbonate on sodium and potassium excretion in man. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1649725/ · DOI 10.1042/cs0810059","model_system":"15 healthy adults; about 19 mmol extra potassium over 24 hours at the higher dose.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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