{"id":"1c7fd0e6-984e-5f9e-8788-c5d6455f2262","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-phytate-calcium","predicate":"reduced","statement":"Zinc absorption fractions were 32.8±2.3%, 26.9±2.4%, 39.4±2.4% and 26.2±2.3% (mean±SE) for moderate-Ca/low-phytate, moderate-Ca/high-phytate, high-Ca/low-phytate and high-Ca/high-phytate menus. Phytate reduced absorption; calcium did not significantly impair it.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"3de13088-68a6-5525-95f0-257da2d872aa","mechanism_event_label":"Phytate reduced zinc uptake in these menus, while extra calcium did not.","subject":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"object":{"id":"957321e4-a5db-5a5d-851b-72069bab3efd","slug":"intestinal-zinc-absorption","display_name":"Intestinal zinc absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3de13088-68a6-5525-95f0-257da2d872aa","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-phytate-calcium-event","event_type":"observed_intervention","label":"Phytate reduced zinc uptake in these menus, while extra calcium did not.","description":"Zinc absorption fractions were 32.8±2.3%, 26.9±2.4%, 39.4±2.4% and 26.2±2.3% (mean±SE) for moderate-Ca/low-phytate, moderate-Ca/high-phytate, high-Ca/low-phytate and high-Ca/high-phytate menus. Phytate reduced absorption; calcium did not significantly impair it.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"measured_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"957321e4-a5db-5a5d-851b-72069bab3efd","slug":"intestinal-zinc-absorption","display_name":"Intestinal zinc absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"absolute_absorption","value_text":"Corresponding absolute absorption: 3.8±0.3, 3.0±0.3, 4.5±0.3 and 3.2±0.3 mg zinc/day (mean±SE).","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"cross_nutrient","value_text":"Calcium (dietary_context); Zinc (measured_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/hunt2009.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"d912d9f2c0890cde2ae13e9de7f1202bf130e661e3f14e13483563f179319f85\", \"utf8_bytes\": 1659}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Two-by-two one-day feeding and 65Zn tracer study in ten healthy women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Approximately 700 versus 1800 mg calcium/day, and 440 versus 1800 mg phytate/day in conventional menus.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short controlled menus in ten women; null calcium effect does not cover every formulation, population or dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Phytate reduced zinc uptake in these menus, while extra calcium did not.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-hunt2009] Dietary calcium does not exacerbate phytate inhibition of zinc absorption by women from conventional diets. (2009). https://pubmed.ncbi.nlm.nih.gov/19176739/ DOI: 10.3945/ajcn.2008.27175","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal absorption","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1e466359-9fb2-5e3c-85d4-193da2eb0127","evidence_kind":"source_excerpt","locator":"Lines 1271-1285","start_line":1271,"end_line":1285,"excerpt":"### zn-clin-phytate-calcium\nZinc absorption fractions were 32.8±2.3%, 26.9±2.4%, 39.4±2.4% and 26.2±2.3% (mean±SE) for moderate-Ca/low-phytate, moderate-Ca/high-phytate, high-Ca/low-phytate and high-Ca/high-phytate menus. Phytate reduced absorption; calcium did not significantly impair it.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Phytate reduced zinc uptake in these menus, while extra calcium did not.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal absorption\nexperimental_model: Two-by-two one-day feeding and 65Zn tracer study in ten healthy women\nlimitations: Short controlled menus in ten women; null calcium effect does not cover every formulation, population or dose.\nexposure: Approximately 700 versus 1800 mg calcium/day, and 440 versus 1800 mg phytate/day in conventional menus.\ncross_nutrient: Calcium (dietary_context); Zinc (measured_nutrient)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/hunt2009.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"d912d9f2c0890cde2ae13e9de7f1202bf130e661e3f14e13483563f179319f85\", \"utf8_bytes\": 1659}\nabsolute_absorption: Corresponding absolute absorption: 3.8±0.3, 3.0±0.3, 4.5±0.3 and 3.2±0.3 mg zinc/day (mean±SE).\n[zn-clin-hunt2009] Dietary calcium does not exacerbate phytate inhibition of zinc absorption by women from conventional diets. (2009). https://pubmed.ncbi.nlm.nih.gov/19176739/ DOI: 10.3945/ajcn.2008.27175","model_system":"Two-by-two one-day feeding and 65Zn tracer study in ten healthy women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-hunt2009] Dietary calcium does not exacerbate phytate inhibition of zinc absorption by women from conventional diets. (2009). https://pubmed.ncbi.nlm.nih.gov/19176739/ DOI: 10.3945/ajcn.2008.27175","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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