{"id":"1c556add-bed0-5076-8d59-f5b711bc53f0","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-ogtt-insulin-null","predicate":"did_not_change","statement":"The same trial found no significant change in insulin levels or the measured body-composition outcomes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"0556e8a8-6327-5586-af72-851809342d7b","mechanism_event_label":"The glucose response did not imply improvement in every endpoint.","subject":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"object":{"id":"251dd8dc-75d5-51e0-a8c0-37f834fe24ab","slug":"human-carnosine-trial-insulin","display_name":"Human insulin response in the 2024 carnosine trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0556e8a8-6327-5586-af72-851809342d7b","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-ogtt-insulin-null-event","event_type":"observed_relationship","label":"The glucose response did not imply improvement in every endpoint.","description":"The same trial found no significant change in insulin levels or the measured body-composition outcomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"251dd8dc-75d5-51e0-a8c0-37f834fe24ab","slug":"human-carnosine-trial-insulin","display_name":"Human insulin response in the 2024 carnosine trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same randomized trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preserve null endpoints alongside positive findings.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The glucose response did not imply improvement in every endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes: A randomised controlled trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38172006/ · DOI 10.1016/j.numecd.2023.10.012","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ef055076-f3e8-5055-8acc-7c5ce696fe4f","evidence_kind":"source_excerpt","locator":"Lines 500-506","start_line":500,"end_line":506,"excerpt":"## carnosine-ogtt-insulin-null\nThe glucose response did not imply improvement in every endpoint.\nThe same trial found no significant change in insulin levels or the measured body-composition outcomes.\nModel: Same randomized trial.\nLimitations: Preserve null endpoints alongside positive findings.\nEvidence access: Primary abstract\nCarnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes: A randomised controlled trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38172006/ · DOI 10.1016/j.numecd.2023.10.012","model_system":"Same randomized trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"469cbc38203db56bd031f9d8a2dd2bfa387713950ca30199511cd137e927aa7a","revision_id":"cc409a15-8b04-50ee-a7ff-d1bf32f686bb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}