{"id":"1c399475-116a-548f-9ec9-589725432a70","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-gpr158-taurine","predicate":"binds_tested","statement":"Taurine competed for GPR158 glycine binding and produced weaker cAMP suppression than glycine in the recombinant assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c2ac5f1e-ce46-53ef-9d71-731d9c392093","mechanism_event_label":"Another nutrient-related molecule reaches the same receptor with a different response.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"c1793375-e328-5a81-940b-046c14ad45fe","slug":"gpr158-recombinant-assay","display_name":"Recombinant GPR158 in the 2023 binding/signaling assays","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"c2ac5f1e-ce46-53ef-9d71-731d9c392093","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-gpr158-taurine-event","event_type":"observed_relationship","label":"Another nutrient-related molecule reaches the same receptor with a different response.","description":"Taurine competed for GPR158 glycine binding and produced weaker cAMP suppression than glycine in the recombinant assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c1793375-e328-5a81-940b-046c14ad45fe","slug":"gpr158-recombinant-assay","display_name":"Recombinant GPR158 in the 2023 binding/signaling assays","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ad57ab75-a572-5b0f-b6a9-0374f57d4a9d","slug":"gpr158-rgs7-gnb5-assay","display_name":"GPR158-associated RGS7/G-beta5 assay complex","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Membrane ligand competition and cell signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Shared binding is not proof of supplement synergy or the same neuronal response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Another nutrient-related molecule reaches the same receptor with a different response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36996198/ · DOI 10.1126/science.add7150","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b153fc83-fe82-5e51-b721-76b247b13a1b","evidence_kind":"source_excerpt","locator":"Lines 242-248","start_line":242,"end_line":248,"excerpt":"## glycine-gpr158-taurine\nAnother nutrient-related molecule reaches the same receptor with a different response.\nTaurine competed for GPR158 glycine binding and produced weaker cAMP suppression than glycine in the recombinant assays.\nModel: Membrane ligand competition and cell signaling.\nLimitations: Shared binding is not proof of supplement synergy or the same neuronal response.\nEvidence access: Primary full text\nOrphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36996198/ · DOI 10.1126/science.add7150","model_system":"Membrane ligand competition and cell signaling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"4fabd2fc8e71ca156c91023e7340be3f5a02ae03e91d3a24b231c2adfb0de0aa","revision_id":"24801e49-34a8-53c3-bdf5-b59143441450","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}