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(2012). https://pubmed.ncbi.nlm.nih.gov/22854042/ DOI: 10.1242/jcs.110114","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial intermembrane space and cytosol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e9c76022-1ce1-52ca-8ae7-6d1a01ec3e17","evidence_kind":"source_excerpt","locator":"Lines 664-675","start_line":664,"end_line":675,"excerpt":"### mo-suox-dimer-order\nSUOX dimerization did not occur in the absence of Moco and followed cofactor insertion.\nCondition category: machinery_impairment\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The enzyme also needs cofactor loading before assembling its mature pair.\norganism: Mammalian/human cell models\ntissue_or_cell_type: Mitochondrial intermembrane space and cytosol\nexperimental_model: Mammalian sulfite-oxidase targeting, cofactor depletion and maturation experiments\nlimitations: Sequential maturation in the studied models; not a universal ranking of nutrient needs.\nexposure: Targeting-sequence constructs and absence of Moco\nevidence_span: {\"source_cache\": \"artifacts/molybdenum-research/22854042.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"01970920183b87fde6830ca30d612aff75fc4b1a30672a3b9cc2f0c408294884\", \"start_char\": 0, \"end_char\": 1268, \"text_sha256\": \"01970920183b87fde6830ca30d612aff75fc4b1a30672a3b9cc2f0c408294884\"}\n[mo-p22854042] Cofactor-dependent maturation of mammalian sulfite oxidase links two mitochondrial import pathways. 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