{"id":"1bc9af55-c4fc-578c-8847-21e5d1dd854a","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-sleep-human-outcomes","predicate":"improves_tested","statement":"In a randomized single-blind crossover study analyzing seven healthy men after partial sleep restriction, 3 g bedtime glycine improved reported fatigue and psychomotor vigilance measures.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2739db5d-ae76-5d3d-b693-5098814237c3","mechanism_event_label":"A small human experiment measured next-day performance rather than proving a molecular pathway.","subject":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"object":{"id":"c152d7cc-9b38-522e-aa77-9ef7094e5eb9","slug":"human-glycine-sleep-restriction-performance","display_name":"Performance after partial sleep restriction in the glycine study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2739db5d-ae76-5d3d-b693-5098814237c3","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-sleep-human-outcomes-event","event_type":"observed_relationship","label":"A small human experiment measured next-day performance rather than proving a molecular pathway.","description":"In a randomized single-blind crossover study analyzing seven healthy men after partial sleep restriction, 3 g bedtime glycine improved reported fatigue and psychomotor vigilance measures.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c152d7cc-9b38-522e-aa77-9ef7094e5eb9","slug":"human-glycine-sleep-restriction-performance","display_name":"Performance after partial sleep restriction in the glycine study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten male company employees enrolled, seven analyzed; 25% sleep restriction for three nights, glycine or placebo 30 minutes before bed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small selected sample, short duration and industry setting limit generalization; rat SCN experiments do not prove the human mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A small human experiment measured next-day performance rather than proving a molecular pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22529837/ · DOI 10.3389/fneur.2012.00061","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0d584f76-8971-545e-a990-7d0dd73a7bf8","evidence_kind":"source_excerpt","locator":"Lines 426-432","start_line":426,"end_line":432,"excerpt":"## glycine-sleep-human-outcomes\nA small human experiment measured next-day performance rather than proving a molecular pathway.\nIn a randomized single-blind crossover study analyzing seven healthy men after partial sleep restriction, 3 g bedtime glycine improved reported fatigue and psychomotor vigilance measures.\nModel: Ten male company employees enrolled, seven analyzed; 25% sleep restriction for three nights, glycine or placebo 30 minutes before bed.\nLimitations: Small selected sample, short duration and industry setting limit generalization; rat SCN experiments do not prove the human mechanism.\nEvidence access: Primary full text\nThe effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22529837/ · DOI 10.3389/fneur.2012.00061","model_system":"Ten male company employees enrolled, seven analyzed; 25% sleep restriction for three nights, glycine or placebo 30 minutes before bed.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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