{"id":"1b9a4aca-08d6-51bf-8468-9e55adb5c23a","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-mgr1-ip-calcium","predicate":"couples_to","statement":"The cloned rat metabotropic glutamate receptor coupled receptor activation to inositol-phosphate/calcium signaling.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9ff9662c-de65-50bc-95e5-82c7a0125e5d","mechanism_event_label":"A glutamate receptor can trigger an internal signaling cascade instead of forming the ion pore itself.","subject":{"id":"efc2fa98-7b66-548e-b69f-4c9bf42167bb","slug":"rat-grm1","display_name":"Rat metabotropic glutamate receptor 1 / Grm1","entity_type_key":"protein"},"object":{"id":"b78430b2-4315-5ecb-833f-45b76994b7e8","slug":"rat-grm1-inositol-calcium-signaling","display_name":"Rat mGluR1 inositol-phosphate/calcium signaling","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9ff9662c-de65-50bc-95e5-82c7a0125e5d","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-mgr1-ip-calcium-event","event_type":"observed_relationship","label":"A glutamate receptor can trigger an internal signaling cascade instead of forming the ion pore itself.","description":"The cloned rat metabotropic glutamate receptor coupled receptor activation to inositol-phosphate/calcium signaling.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"efc2fa98-7b66-548e-b69f-4c9bf42167bb","slug":"rat-grm1","display_name":"Rat metabotropic glutamate receptor 1 / Grm1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b78430b2-4315-5ecb-833f-45b76994b7e8","slug":"rat-grm1-inositol-calcium-signaling","display_name":"Rat mGluR1 inositol-phosphate/calcium signaling","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7005bbc2-d4b5-5903-b776-94dd2288d35f","slug":"ip3","display_name":"IP3","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat receptor cloning and functional expression study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not demonstrate that oral inositol or calcium increases the response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A glutamate receptor can trigger an internal signaling cascade instead of forming the ion pore itself.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sequence and expression of a metabotropic glutamate receptor. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1847995/ · DOI 10.1038/349760a0","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e6ddbcd7-8737-5a4f-80c6-8fa431abde02","evidence_kind":"source_excerpt","locator":"Lines 258-264","start_line":258,"end_line":264,"excerpt":"## glutamate-mgr1-ip-calcium\nA glutamate receptor can trigger an internal signaling cascade instead of forming the ion pore itself.\nThe cloned rat metabotropic glutamate receptor coupled receptor activation to inositol-phosphate/calcium signaling.\nModel: Rat receptor cloning and functional expression study.\nLimitations: This does not demonstrate that oral inositol or calcium increases the response.\nEvidence access: Primary abstract\nSequence and expression of a metabotropic glutamate receptor. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1847995/ · DOI 10.1038/349760a0","model_system":"Rat receptor cloning and functional expression study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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