{"id":"1b8140fc-af82-593c-86ac-5d33c9afcfff","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-sulfate-uptake-slco2b1","predicate":"transports","statement":"Myricetin 3′-O-sulfate was a substrate of human SLCO2B1.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"89c6797b-ffd9-5abe-b125-a974896099d8","mechanism_event_label":"The sulfate is transported, not simply inactive waste.","subject":{"id":"4f63ef8a-7938-5fb2-bc0f-cca962df8510","slug":"slco2b1","display_name":"Human organic anion transporting polypeptide 2B1 / SLCO2B1","entity_type_key":"protein"},"object":{"id":"b71fca58-3e61-5eed-bfa5-4465fcc9407e","slug":"myricetin-3-prime-o-sulfate","display_name":"Myricetin 3′-O-sulfate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"89c6797b-ffd9-5abe-b125-a974896099d8","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-sulfate-uptake-slco2b1-event","event_type":"observed_relationship","label":"The sulfate is transported, not simply inactive waste.","description":"Myricetin 3′-O-sulfate was a substrate of human SLCO2B1.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4f63ef8a-7938-5fb2-bc0f-cca962df8510","slug":"slco2b1","display_name":"Human organic anion transporting polypeptide 2B1 / SLCO2B1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b71fca58-3e61-5eed-bfa5-4465fcc9407e","slug":"myricetin-3-prime-o-sulfate","display_name":"Myricetin 3′-O-sulfate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Overexpressing-cell uptake with flavonoid fluorescence method.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a quantified human tissue delivery rate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The sulfate is transported, not simply inactive waste.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion-transporting polypeptides (OATP1B1 and OATP2B1). · 2024 · https://pubmed.ncbi.nlm.nih.gov/39344282/ · DOI 10.1002/prp2.70021","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Recorded as a substrate in the OATP2B1 uptake assay.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"Recorded as a substrate in the OATP2B1 uptake assay.","entity":null}],"evidence":[{"id":"4f516c54-5b15-59e7-bfc6-eb421eec70e2","evidence_kind":"source_excerpt","locator":"Lines 212-218","start_line":212,"end_line":218,"excerpt":"## myricetin-sulfate-uptake-slco2b1\nThe sulfate is transported, not simply inactive waste.\nMyricetin 3′-O-sulfate was a substrate of human SLCO2B1.\nModel: Overexpressing-cell uptake with flavonoid fluorescence method.\nLimitations: Not a quantified human tissue delivery rate.\nEvidence access: Primary full text\nInteraction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion-transporting polypeptides (OATP1B1 and OATP2B1). · 2024 · https://pubmed.ncbi.nlm.nih.gov/39344282/ · DOI 10.1002/prp2.70021","model_system":"Overexpressing-cell uptake with flavonoid fluorescence method.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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