{"id":"1b404178-651c-5bb3-802f-d38c771d5363","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mettl16-u6","predicate":"methylates","statement":"METTL16 was identified as a SAM-dependent U6 snRNA m6A methyltransferase.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"248946c0-caec-5980-a78f-64ff8e1d3c7e","mechanism_event_label":"The same enzyme also modifies RNA used in splicing.","subject":{"id":"466b1102-12e9-5241-a335-59fdf4152ef4","slug":"mettl16","display_name":"Human RNA methyltransferase / METTL16","entity_type_key":"protein"},"object":{"id":"2a1413df-b2d1-5b26-b1bd-1e21c403e131","slug":"human-u6-snrna","display_name":"Human U6 small nuclear RNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"248946c0-caec-5980-a78f-64ff8e1d3c7e","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mettl16-u6-event","event_type":"observed_relationship","label":"The same enzyme also modifies RNA used in splicing.","description":"METTL16 was identified as a SAM-dependent U6 snRNA m6A methyltransferase.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"466b1102-12e9-5241-a335-59fdf4152ef4","slug":"mettl16","display_name":"Human RNA methyltransferase / METTL16","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a1413df-b2d1-5b26-b1bd-1e21c403e131","slug":"human-u6-snrna","display_name":"Human U6 small nuclear RNA","entity_type_key":"rna"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human RNA methylation/biochemical study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No claim that every splicing event is controlled by dietary methionine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same enzyme also modifies RNA used in splicing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28525753/ · DOI 10.1016/j.cell.2017.05.003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0260081e-728c-5b2a-9933-15f2171a60bb","evidence_kind":"source_excerpt","locator":"Lines 268-274","start_line":268,"end_line":274,"excerpt":"## methionine-mettl16-u6\nThe same enzyme also modifies RNA used in splicing.\nMETTL16 was identified as a SAM-dependent U6 snRNA m6A methyltransferase.\nModel: Human RNA methylation/biochemical study.\nLimitations: No claim that every splicing event is controlled by dietary methionine.\nEvidence access: Primary abstract\nThe U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28525753/ · DOI 10.1016/j.cell.2017.05.003","model_system":"Human RNA methylation/biochemical study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d969b004-ccc2-5bb4-9109-8ac649137ad1","stable_key":"import-41a89233-da9a-5b7b-9c18-e19bbadcfe2d","title":"L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f1c706ef72932eed85df234b6c3304158d503d626a63c69b02a453c162700d26","revision_id":"549035e0-3a72-550a-8a55-e8c5baa51b0d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}