{"id":"1af35f5f-df78-549f-a30c-ed765d17f528","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-radical-versus-membrane","predicate":"scavenges","statement":"Myricetin reacted with galvinoxyl radicals faster and with greater stoichiometric capacity than alpha-tocopherol, yet failed to protect the tested vitamin-E-deficient microsomes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2205fe93-6592-5a46-96d3-85f831aed05b","mechanism_event_label":"A chemical antioxidant ranking is not membrane protection.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"c0287090-b882-56c3-9930-f87f2a9a2f5a","slug":"galvinoxyl-radical-reduction","display_name":"Cell-free galvinoxyl radical reduction","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2205fe93-6592-5a46-96d3-85f831aed05b","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-radical-versus-membrane-event","event_type":"observed_relationship","label":"A chemical antioxidant ranking is not membrane protection.","description":"Myricetin reacted with galvinoxyl radicals faster and with greater stoichiometric capacity than alpha-tocopherol, yet failed to protect the tested vitamin-E-deficient microsomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0287090-b882-56c3-9930-f87f2a9a2f5a","slug":"galvinoxyl-radical-reduction","display_name":"Cell-free galvinoxyl radical reduction","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Radical assay and microsomal TBARS comparison; species unresolved in accessed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Synthetic lipophilic analogues in this paper are separate compounds; their activity is not assigned to myricetin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A chemical antioxidant ranking is not membrane protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15080911/ · DOI 10.1016/j.bmc.2004.02.031","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6beefbd4-ed23-5628-a0ba-63e45551cbb5","evidence_kind":"source_excerpt","locator":"Lines 380-386","start_line":380,"end_line":386,"excerpt":"## myricetin-radical-versus-membrane\nA chemical antioxidant ranking is not membrane protection.\nMyricetin reacted with galvinoxyl radicals faster and with greater stoichiometric capacity than alpha-tocopherol, yet failed to protect the tested vitamin-E-deficient microsomes.\nModel: Radical assay and microsomal TBARS comparison; species unresolved in accessed abstract.\nLimitations: Synthetic lipophilic analogues in this paper are separate compounds; their activity is not assigned to myricetin.\nEvidence access: Primary abstract\nPotential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15080911/ · DOI 10.1016/j.bmc.2004.02.031","model_system":"Radical assay and microsomal TBARS comparison; species unresolved in accessed abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}