{"id":"1ad1b6f0-bc8f-56b8-98c2-321d3719344a","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-urine-output","predicate":"increases","statement":"Urine volume increased without a marked change in urine urate concentration.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"74c9424b-7aac-5ac0-b9b4-e22918bf2659","mechanism_event_label":"More urate could leave through greater urine output.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"6d426839-1021-549b-9a6a-5f00022d77fc","slug":"mouse-urine-output","display_name":"Mouse urine output","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"74c9424b-7aac-5ac0-b9b4-e22918bf2659","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-urine-output-event","event_type":"biochemical_relationship","label":"More urate could leave through greater urine output.","description":"Urine volume increased without a marked change in urine urate concentration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc991604-a37a-5362-9994-f171961e37b4","slug":"mouse-urinary-urate-excretion","display_name":"Mouse urinary urate excretion","entity_type_key":"cellular_process"},"role":"associated_outcome","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6d426839-1021-549b-9a6a-5f00022d77fc","slug":"mouse-urine-output","display_name":"Mouse urine output","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/32116724.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f18a5e0ea5cd0f421555870fbfcaede81ecb40cd62a7de27f356d6addf076ee5\", \"start_char\": 0, \"end_char\": 1810, \"text_sha256\": \"f18a5e0ea5cd0f421555870fbfcaede81ecb40cd62a7de27f356d6addf076ee5\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse hyperuricemic nephropathy experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin in the study-specific nephropathy model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different model from earlier oxonate experiments; associations do not prove AQP2 mediation. Null expression results do not rule out changes in activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More urate could leave through greater urine output.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p32116724] Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion. (2020). https://pubmed.ncbi.nlm.nih.gov/32116724/ DOI: 10.3389/fphar.2020.00049","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney and metabolic-cage urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8bc8b04d-b1cf-550a-9c20-6ea7888fda51","evidence_kind":"source_excerpt","locator":"Lines 1030-1041","start_line":1030,"end_line":1041,"excerpt":"### mangiferin-urine-output\nUrine volume increased without a marked change in urine urate concentration.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More urate could leave through greater urine output.\norganism: Mus musculus\ntissue_or_cell_type: Kidney and metabolic-cage urine\nexperimental_model: Mouse hyperuricemic nephropathy experiment\nlimitations: Different model from earlier oxonate experiments; associations do not prove AQP2 mediation. Null expression results do not rule out changes in activity.\nexposure: Mangiferin in the study-specific nephropathy model\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/32116724.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f18a5e0ea5cd0f421555870fbfcaede81ecb40cd62a7de27f356d6addf076ee5\", \"start_char\": 0, \"end_char\": 1810, \"text_sha256\": \"f18a5e0ea5cd0f421555870fbfcaede81ecb40cd62a7de27f356d6addf076ee5\"}\n[mangiferin-p32116724] Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion. (2020). https://pubmed.ncbi.nlm.nih.gov/32116724/ DOI: 10.3389/fphar.2020.00049","model_system":"Mouse hyperuricemic nephropathy experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mangiferin-p32116724] Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion. (2020). https://pubmed.ncbi.nlm.nih.gov/32116724/ DOI: 10.3389/fphar.2020.00049","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"267f942a-695a-5b62-a858-f71c06321ff5","stable_key":"import-475ea55a-65e9-51c3-a539-738a6a8f683f","title":"Mangiferin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"295cb3a13742b3caeed19347ffcbc7863f5372d983da1625a942428919b4dc98","revision_id":"d9c2ee89-ff22-5e86-9d7f-7cb7e17f9ed2","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}