{"id":"1aab75f1-fa37-5062-94ba-5d3dabfca5d6","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-tocopherol-null","predicate":"no_additive_scavenging_with","statement":"Co-encapsulating astaxanthin and alpha-tocopherol did not produce an additive antioxidative effect in the same liposome study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a5fc30a8-ee4f-5efe-8aeb-cb52363f0db7","mechanism_event_label":"The result for tocotrienols did not carry over to alpha-tocopherol.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a5fc30a8-ee4f-5efe-8aeb-cb52363f0db7","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-tocopherol-null-event","event_type":"observed_relationship","label":"The result for tocotrienols did not carry over to alpha-tocopherol.","description":"Co-encapsulating astaxanthin and alpha-tocopherol did not produce an additive antioxidative effect in the same liposome study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free combination comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different vitamin E molecules are separate records; a null combination result does not mean either alone lacks antioxidant activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The result for tocotrienols did not carry over to alpha-tocopherol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27698536/ · DOI 10.3164/jcbn.15-153","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"822e8526-0839-5d86-8b3c-a9d66cc00757","evidence_kind":"source_excerpt","locator":"Lines 198-204","start_line":198,"end_line":204,"excerpt":"## astaxanthin-tocopherol-null\nThe result for tocotrienols did not carry over to alpha-tocopherol.\nCo-encapsulating astaxanthin and alpha-tocopherol did not produce an additive antioxidative effect in the same liposome study.\nModel: Cell-free combination comparison.\nLimitations: Different vitamin E molecules are separate records; a null combination result does not mean either alone lacks antioxidant activity.\nEvidence access: Primary abstract\nSynergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27698536/ · DOI 10.3164/jcbn.15-153","model_system":"Cell-free combination comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}