{"id":"1aa4c3dc-dc64-51b9-b722-0277c80e6570","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-geraldol-tumor","predicate":"accumulates_in","statement":"Geraldol reached higher tumor concentrations than fisetin in the mouse Lewis lung tumor experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c2b55cf6-6bd9-56d9-a948-1ed79280d9a0","mechanism_event_label":"A metabolite may reach a target differently.","subject":{"id":"9fdb2610-ab87-5de2-9658-ed83bc42b3fc","slug":"geraldol","display_name":"Geraldol / 3-prime-O-methylfisetin","entity_type_key":"small_molecule"},"object":{"id":"f1723e13-4fba-5c0d-acb2-b1dafafa811b","slug":"mouse-lewis-tumor-geraldol-exposure","display_name":"Geraldol exposure in mouse Lewis lung tumors","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c2b55cf6-6bd9-56d9-a948-1ed79280d9a0","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-geraldol-tumor-event","event_type":"observed_relationship","label":"A metabolite may reach a target differently.","description":"Geraldol reached higher tumor concentrations than fisetin in the mouse Lewis lung tumor experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9fdb2610-ab87-5de2-9658-ed83bc42b3fc","slug":"geraldol","display_name":"Geraldol / 3-prime-O-methylfisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f1723e13-4fba-5c0d-acb2-b1dafafa811b","slug":"mouse-lewis-tumor-geraldol-exposure","display_name":"Geraldol exposure in mouse Lewis lung tumors","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse tumor distribution after fisetin administration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Distribution does not prove the metabolite explains every anticancer response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A metabolite may reach a target differently.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21840301/ · DOI 10.1016/j.bcp.2011.07.097","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6248b6bd-f148-50ef-8e2b-25bf4f994e46","evidence_kind":"source_excerpt","locator":"Lines 40-46","start_line":40,"end_line":46,"excerpt":"## fisetin-geraldol-tumor\nA metabolite may reach a target differently.\nGeraldol reached higher tumor concentrations than fisetin in the mouse Lewis lung tumor experiment.\nModel: Mouse tumor distribution after fisetin administration.\nLimitations: Distribution does not prove the metabolite explains every anticancer response.\nEvidence access: Primary abstract\nFisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21840301/ · DOI 10.1016/j.bcp.2011.07.097","model_system":"Mouse tumor distribution after fisetin administration.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}