{"id":"1a5baf4e-f45d-5f1c-b18c-be85ceed3a1a","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-statin-serum-muscle","predicate":"reduces_serum_but_not_necessarily","statement":"After four weeks, serum ubiquinone decreased while muscle ubiquinone increased; no participant developed myopathy.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"70d0e2e0-47d9-5e25-a5b3-d40b4e7305f3","mechanism_event_label":"A falling blood result did not mean falling muscle supply in this study.","subject":{"id":"b7de977d-fed9-5b1c-8138-fd951442b067","slug":"simvastatin","display_name":"Simvastatin","entity_type_key":"small_molecule"},"object":{"id":"9c185815-74b8-5542-b236-f302b620c1e8","slug":"coq-muscle-concentration","display_name":"Muscle coenzyme Q10 concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"70d0e2e0-47d9-5e25-a5b3-d40b4e7305f3","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-statin-serum-muscle-event","event_type":"observed_intervention","label":"A falling blood result did not mean falling muscle supply in this study.","description":"After four weeks, serum ubiquinone decreased while muscle ubiquinone increased; no participant developed myopathy.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"role":"opposite_measurement_direction","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b7de977d-fed9-5b1c-8138-fd951442b067","slug":"simvastatin","display_name":"Simvastatin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9c185815-74b8-5542-b236-f302b620c1e8","slug":"coq-muscle-concentration","display_name":"Muscle coenzyme Q10 concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/7828383.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e6aac0f5f784ab8a43755c6c878ea010b8673acc19bfa41f7a1272880c745197\", \"start_char\": 0, \"end_char\": 800, \"text_sha256\": \"e6aac0f5f784ab8a43755c6c878ea010b8673acc19bfa41f7a1272880c745197\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Short-term treatment with serum and muscle sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Four weeks of simvastatin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small short-term study; serum and muscle moved differently. No participants developed myopathy; this does not exclude other regimens or vulnerable patients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Humans with hypercholesterolemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A falling blood result did not mean falling muscle supply in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p7828383] Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. (1995). https://pubmed.ncbi.nlm.nih.gov/7828383/ DOI: 10.1016/0009-9236(95)90266-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum versus skeletal-muscle CoQ","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cce1e1b1-090e-5a8f-9ac9-4496d0d4e2df","evidence_kind":"source_excerpt","locator":"Lines 918-929","start_line":918,"end_line":929,"excerpt":"### coq10-statin-serum-muscle\nAfter four weeks, serum ubiquinone decreased while muscle ubiquinone increased; no participant developed myopathy.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A falling blood result did not mean falling muscle supply in this study.\norganism: Humans with hypercholesterolemia\ntissue_or_cell_type: Serum versus skeletal-muscle CoQ\nexperimental_model: Short-term treatment with serum and muscle sampling\nlimitations: Small short-term study; serum and muscle moved differently. No participants developed myopathy; this does not exclude other regimens or vulnerable patients.\nexposure: Four weeks of simvastatin\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/7828383.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e6aac0f5f784ab8a43755c6c878ea010b8673acc19bfa41f7a1272880c745197\", \"start_char\": 0, \"end_char\": 800, \"text_sha256\": \"e6aac0f5f784ab8a43755c6c878ea010b8673acc19bfa41f7a1272880c745197\"}\n[coq10-p7828383] Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. (1995). https://pubmed.ncbi.nlm.nih.gov/7828383/ DOI: 10.1016/0009-9236(95)90266-x","model_system":"Short-term treatment with serum and muscle sampling","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p7828383] Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. (1995). https://pubmed.ncbi.nlm.nih.gov/7828383/ DOI: 10.1016/0009-9236(95)90266-x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fc6c2f3b-14a3-59de-848e-ca1c02fee1df","stable_key":"import-3b5aff9b-4086-5574-bfb4-3ea49ba520d7","title":"Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"053f9a6f6c17321fa9fd271486d7f20a86a49b237424108de7dc8663372e73bf","revision_id":"028900ce-8ca4-5d13-8c86-6e327c071e64","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}