{"id":"1a0a2c32-bd43-5c17-9f0c-5420140fd2e8","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-odor-convergence","predicate":"enhances_tested","statement":"Glutamate taste with a consonant savory odor produced supralinear fMRI responses in medial orbitofrontal and pregenual cingulate regions, related to flavor pleasantness.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bf634700-8368-5144-9e17-a49c49d77b02","mechanism_event_label":"Smell changes the perceived flavor through sensory convergence.","subject":{"id":"57299d06-583d-516a-a27e-ff495fd3186d","slug":"human-consonant-savory-odor","display_name":"Consonant savory odor in human taste experiments","entity_type_key":"cellular_process"},"object":{"id":"daa242f5-20c8-5661-946f-be688464d72b","slug":"human-glutamate-odor-cortical-response","display_name":"Human cortical response to glutamate taste with savory odor","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bf634700-8368-5144-9e17-a49c49d77b02","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-odor-convergence-event","event_type":"observed_relationship","label":"Smell changes the perceived flavor through sensory convergence.","description":"Glutamate taste with a consonant savory odor produced supralinear fMRI responses in medial orbitofrontal and pregenual cingulate regions, related to flavor pleasantness.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"57299d06-583d-516a-a27e-ff495fd3186d","slug":"human-consonant-savory-odor","display_name":"Consonant savory odor in human taste experiments","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"daa242f5-20c8-5661-946f-be688464d72b","slug":"human-glutamate-odor-cortical-response","display_name":"Human cortical response to glutamate taste with savory odor","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human sensory ratings and fMRI.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"BOLD activation is not evidence that ingested glutamate crossed the blood-brain barrier.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Smell changes the perceived flavor through sensory convergence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Umami: a delicious flavor formed by convergence of taste and olfactory pathways in the human brain. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17432971/ · DOI 10.1111/j.1460-9568.2007.05445.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e2219f82-5abc-5dbd-aaa2-0468ff48d88c","evidence_kind":"source_excerpt","locator":"Lines 146-152","start_line":146,"end_line":152,"excerpt":"## monosodium-glutamate-odor-convergence\nSmell changes the perceived flavor through sensory convergence.\nGlutamate taste with a consonant savory odor produced supralinear fMRI responses in medial orbitofrontal and pregenual cingulate regions, related to flavor pleasantness.\nModel: Human sensory ratings and fMRI.\nLimitations: BOLD activation is not evidence that ingested glutamate crossed the blood-brain barrier.\nEvidence access: Primary abstract\nUmami: a delicious flavor formed by convergence of taste and olfactory pathways in the human brain. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17432971/ · DOI 10.1111/j.1460-9568.2007.05445.x","model_system":"Human sensory ratings and fMRI.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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