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(2020). https://pubmed.ncbi.nlm.nih.gov/32694791/ DOI: 10.1038/s42255-020-0222-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral gavage","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Intestinal processing and hepatic lipogenesis","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4afccf14-0134-5c0a-945d-6148e9e06959","evidence_kind":"source_excerpt","locator":"Lines 197-207","start_line":197,"end_line":207,"excerpt":"## hfcs-delivery-rate\nDividing the same fructose dose over 45 minutes reduced hepatic lipogenesis relative to a single mouse gavage bolus.\nModel/species: Tracer experiments in mice\nTissue: Intestinal processing and hepatic lipogenesis\nExposure: 2 g/kg fructose plus matched glucose once versus four 0.5 g/kg fructose doses 15 min apart\nRoute: Oral gavage\nDuration: Equal total dose delivered over 45 min versus one bolus\nExposure scope: Component mixture\nLimits: Same sugar amount with different delivery rates; does not quantify a recommended human rate.\nReference: The small intestine shields the liver from fructose-induced steatosis. (2020). https://pubmed.ncbi.nlm.nih.gov/32694791/ DOI: 10.1038/s42255-020-0222-9\nAccess: Primary full-text methods/results and metadata inspected.","model_system":"Tracer experiments in mice","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. 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