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HCAR2 historically GPR109A/HM74A in humans; mouse receptor PUMA-G. The location of the responsible immune cells was inferred, not every human flush directly measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Niacin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"niacin","display_name":"Niacin (vitamin B3)","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The mouse flushing signal required the receptor in a population supplied by bone marrow.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nia-clin-benyo2005] GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. 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HCAR2 historically GPR109A/HM74A in humans; mouse receptor PUMA-G. The location of the responsible immune cells was inferred, not every human flush directly measured.\nexposure: Nicotinic acid; receptor or cyclooxygenase deletion; wild-type bone-marrow rescue\ncross_nutrient: Nicotinic acid (agonist); Mouse Hcar2 / PUMA-G receptor (affected_receptor)\nevidence_span: {\"source_cache\": \"artifacts/niacin-clinical-sources/benyo2005.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"21dedb52cbd8fccaf810dabec7837e471525e0a5462827b21437d2f7b30c44a2\", \"start_char\": 0, \"end_char\": 1388, \"text_sha256\": \"21dedb52cbd8fccaf810dabec7837e471525e0a5462827b21437d2f7b30c44a2\"}\n[nia-clin-benyo2005] GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. 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