{"id":"18a86adb-1c67-536a-b60b-51fef7fb0eab","stable_key":"availability:selenop-tissue-selective-delivery:1","predicate":"can_reduce_circulating_availability_of","statement":"Reduced selenium intake or availability can lower circulating SELENOP and tissue selenium delivery.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"source_reported: Animal model and biochemical transport biology; source-derived unverified synthesis.","direction":"negative","is_public":true,"mechanism_event_id":"56c7c2fd-1efd-5b5b-9d45-63e25d9b55c7","mechanism_event_label":"Reduced selenium intake or availability can lower circulating SELENOP and tissue selenium delivery.","subject":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"object":{"id":"c7fbd153-6444-50b2-a8be-6936e352a11c","slug":"selenop","display_name":"SELENOP","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"56c7c2fd-1efd-5b5b-9d45-63e25d9b55c7","stable_key":"availability:selenop-tissue-selective-delivery:1","event_type":"availability_dependent_change","label":"Reduced selenium intake or availability can lower circulating SELENOP and tissue selenium delivery.","description":"Dietary selenium availability declines. Tissue-selective distribution, largely from experimental models; relative retention differs from absolute protection.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"condition_input","stoichiometry":null,"state_label":"Dietary selenium availability declines.","sequence_order":0,"notes":""},{"entity":{"id":"c7fbd153-6444-50b2-a8be-6936e352a11c","slug":"selenop","display_name":"SELENOP","entity_type_key":"protein"},"role":"affected_component","stoichiometry":null,"state_label":"Dietary selenium availability declines.","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"Dietary selenium availability declines.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_scope","value_text":"Tissue-selective distribution, largely from experimental models; relative retention differs from absolute protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"There is no fixed human organ sacrifice sequence. Low circulating SELENOP can also reflect inflammation, and receptor disruption is a distinct machinery state.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"61bb86d2-ba06-5624-a0b3-d36e3cb44599","evidence_kind":"source_passage","locator":"lines 783-791","start_line":783,"end_line":791,"excerpt":"selenium intake / availability ↓\n        │\n        ▼\ncentral selenium metabolism and Sec-tRNA supply become constrained\n        │\n        ├─ tRNA^[Ser]Sec modification can shift (including Um34 / FTSJ1 biology)\n        ├─ SECIS-dependent UGA recoding changes\n        ├─ selected transcripts can undergo stronger repression / NMD\n        └─ circulating SELENOP and tissue delivery can fall","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}}],"relations":[],"conflicts":[],"corrections":[],"research":null}