{"id":"1870615e-2ddf-59d9-a3a3-c75312bce335","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-statin-plasma-carriers","predicate":"reduces","statement":"Simvastatin, alone or with ezetimibe, lowered plasma CoQ; CoQ change correlated with LDL-cholesterol change and the CoQ-to-LDL ratio increased.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"96f00bae-583a-5efe-8620-a0385231d650","mechanism_event_label":"The blood concentration also depends on the particles carrying CoQ.","subject":{"id":"b7de977d-fed9-5b1c-8138-fd951442b067","slug":"simvastatin","display_name":"Simvastatin","entity_type_key":"small_molecule"},"object":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"96f00bae-583a-5efe-8620-a0385231d650","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-statin-plasma-carriers-event","event_type":"observed_intervention","label":"The blood concentration also depends on the particles carrying CoQ.","description":"Simvastatin, alone or with ezetimibe, lowered plasma CoQ; CoQ change correlated with LDL-cholesterol change and the CoQ-to-LDL ratio increased.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a7819e-f424-536b-a941-54e179796aab","slug":"ezetimibe","display_name":"Ezetimibe","entity_type_key":"small_molecule"},"role":"combination_arm","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b7de977d-fed9-5b1c-8138-fd951442b067","slug":"simvastatin","display_name":"Simvastatin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/16872244.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"65abd11b5f58ce1125f554d52ed5203575d7a3ba0d20b789abce16148f3b5e27\", \"start_char\": 0, \"end_char\": 2245, \"text_sha256\": \"65abd11b5f58ce1125f554d52ed5203575d7a3ba0d20b789abce16148f3b5e27\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized three-arm parallel study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Simvastatin 40 mg/day, ezetimibe 10 mg/day or both for 14 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Plasma measurements and correlation; neither tissue CoQ nor mitochondrial dysfunction was demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"72 healthy men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The blood concentration also depends on the particles carrying CoQ.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p16872244] Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. (2006). https://pubmed.ncbi.nlm.nih.gov/16872244/ DOI: 10.2165/00002018-200629080-00007","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma CoQ and lipoprotein concentrations","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"83934164-0c38-5f3a-9fe5-1e4484a62c8a","evidence_kind":"source_excerpt","locator":"Lines 931-942","start_line":931,"end_line":942,"excerpt":"### coq10-statin-plasma-carriers\nSimvastatin, alone or with ezetimibe, lowered plasma CoQ; CoQ change correlated with LDL-cholesterol change and the CoQ-to-LDL ratio increased.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The blood concentration also depends on the particles carrying CoQ.\norganism: 72 healthy men\ntissue_or_cell_type: Plasma CoQ and lipoprotein concentrations\nexperimental_model: Randomized three-arm parallel study\nlimitations: Plasma measurements and correlation; neither tissue CoQ nor mitochondrial dysfunction was demonstrated.\nexposure: Simvastatin 40 mg/day, ezetimibe 10 mg/day or both for 14 days\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/16872244.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"65abd11b5f58ce1125f554d52ed5203575d7a3ba0d20b789abce16148f3b5e27\", \"start_char\": 0, \"end_char\": 2245, \"text_sha256\": \"65abd11b5f58ce1125f554d52ed5203575d7a3ba0d20b789abce16148f3b5e27\"}\n[coq10-p16872244] Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. 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