{"id":"18581a3c-6e63-5a4f-a196-8d88d598047e","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:thiamine-allithiamine","predicate":"reported_relationship","statement":"Allicin and thiamine form thiamine allyl disulfide, identified as allithiamine in the original chemistry report.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4197ad12-3c09-53ea-908b-d0e409e361f8","mechanism_event_label":"Allicin and thiamine form thiamine allyl disulfide, identified as allithiamine in the original chemistry report.","subject":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"object":{"id":"222eb1f3-da5a-5de1-83e6-b93a08f30462","slug":"allithiamine","display_name":"Allithiamine / thiamine allyl disulfide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"4197ad12-3c09-53ea-908b-d0e409e361f8","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:thiamine-allithiamine-event","event_type":"biochemical_relationship","label":"Allicin and thiamine form thiamine allyl disulfide, identified as allithiamine in the original chemistry report.","description":"**Vitamin B1 chemistry.** The original allithiamine report identified thiamine allyl disulfide as a product of reaction between allicin and thiamine. This creates a real chemical connection to vitamin B1. It does not establish how much forms after eating garlic, clinical correction of thiamine deficiency, or superiority of garlic over thiamine treatment. Allithiamine is distinct from thiamine tetrahydrofurfuryl disulfide and other synthetic derivatives. [Fujiwara 1954](https://www.jstage.jst.go.jp/article/biochemistry1922/41/1/41_1_29/_article)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"222eb1f3-da5a-5de1-83e6-b93a08f30462","slug":"allithiamine","display_name":"Allithiamine / thiamine allyl disulfide","entity_type_key":"small_molecule"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"reacting nutrient","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary publisher abstract reviewed; chemical identification only. Detailed reaction conditions, human absorption and therapeutic comparisons were not extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Historical chemical identification; publisher abstract; full reaction conditions not extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No quantified gastrointestinal yield, clinical B1-deficiency rescue, or equivalence to TTFD inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Allicin and thiamine form thiamine allyl disulfide, identified as allithiamine in the original chemistry report.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"ALLITHIAMINE A NEWLY FOUND DERIVATIVE OF VITAMIN B1. I. DISCOVERY OF ALLITHIAMINE | 1954 | https://www.jstage.jst.go.jp/article/biochemistry1922/41/1/41_1_29/_article","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 61-61; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"33a76524-04e9-505f-9fd3-fb6c2caad2b8","evidence_kind":"source_excerpt","locator":"Lines 61-61","start_line":61,"end_line":61,"excerpt":"**Vitamin B1 chemistry.** The original allithiamine report identified thiamine allyl disulfide as a product of reaction between allicin and thiamine. This creates a real chemical connection to vitamin B1. It does not establish how much forms after eating garlic, clinical correction of thiamine deficiency, or superiority of garlic over thiamine treatment. Allithiamine is distinct from thiamine tetrahydrofurfuryl disulfide and other synthetic derivatives. [Fujiwara 1954](https://www.jstage.jst.go.jp/article/biochemistry1922/41/1/41_1_29/_article)","model_system":"Historical chemical identification; publisher abstract; full reaction conditions not extracted.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}