{"id":"18496c74-b8fb-5fea-b6fc-ede6b32c2404","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-rat-comt-blockade","predicate":"inhibition_changes_disposition","statement":"Entacapone coadministration reduced methylated luteolin products and increased circulating luteolin in rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d7792afd-8d60-5f2f-9d4b-db3de99b0ae4","mechanism_event_label":"Blocking one metabolic exit increased parent exposure.","subject":{"id":"0add90f0-87f3-5f87-aace-59bf1abda533","slug":"rat-comt","display_name":"Rat catechol O-methyltransferase","entity_type_key":"protein"},"object":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d7792afd-8d60-5f2f-9d4b-db3de99b0ae4","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-rat-comt-blockade-event","event_type":"observed_relationship","label":"Blocking one metabolic exit increased parent exposure.","description":"Entacapone coadministration reduced methylated luteolin products and increased circulating luteolin in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0add90f0-87f3-5f87-aace-59bf1abda533","slug":"rat-comt","display_name":"Rat catechol O-methyltransferase","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"623c2c13-9faa-5388-ad7e-31169a58c484","slug":"chrysoeriol","display_name":"Chrysoeriol / 3′-O-methylluteolin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bf4740f4-99fb-500c-94f8-381d5a49dbd9","slug":"diosmetin","display_name":"Diosmetin / 4′-O-methylluteolin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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primary-abstract references and experimental limitations individually identified. 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