{"id":"181f32d1-abd5-51f1-90c6-c1ff453c1289","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-glutamate-acute","predicate":"acutely_inhibits","statement":"Acute lithium exposure lowered glutamate-uptake capacity in mouse cortical preparations without changing apparent substrate affinity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"da510b99-a4e7-5986-82fb-9d9f4bd45b42","mechanism_event_label":"An immediate effect can differ from long-term adaptation.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"f75ea221-a9bd-5ce1-8525-0781e274558f","slug":"mouse-cortical-glutamate-uptake","display_name":"Mouse cortical presynaptic glutamate uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"da510b99-a4e7-5986-82fb-9d9f4bd45b42","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-glutamate-acute-event","event_type":"observed_relationship","label":"An immediate effect can differ from long-term adaptation.","description":"Acute lithium exposure lowered glutamate-uptake capacity in mouse cortical preparations without changing apparent substrate affinity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f75ea221-a9bd-5ce1-8525-0781e274558f","slug":"mouse-cortical-glutamate-uptake","display_name":"Mouse cortical presynaptic glutamate uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cortical slices and synaptosomes; concentration-response experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not merge acute addition with chronic in-vivo treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"An immediate effect can differ from long-term adaptation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9653192/ · DOI 10.1073/pnas.95.14.8363","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b8e812f8-6ca5-53e7-a596-6e404eb03939","evidence_kind":"source_excerpt","locator":"Lines 232-238","start_line":232,"end_line":238,"excerpt":"## lithium-glutamate-acute\nAn immediate effect can differ from long-term adaptation.\nAcute lithium exposure lowered glutamate-uptake capacity in mouse cortical preparations without changing apparent substrate affinity.\nModel: Cortical slices and synaptosomes; concentration-response experiments.\nLimitations: Do not merge acute addition with chronic in-vivo treatment.\nEvidence access: Primary abstract\nLithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9653192/ · DOI 10.1073/pnas.95.14.8363","model_system":"Cortical slices and synaptosomes; concentration-response experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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