{"id":"18095b22-4b3e-5465-b374-63d27e724183","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-duodenal-grm4","predicate":"pharmacologically_implicated_in","statement":"mGluR4 agonists mimicked and an antagonist inhibited glutamate-associated pH and mucus responses.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f62633fa-8291-5e1b-ae06-c3b07199c653","mechanism_event_label":"Receptor probes help locate a step.","subject":{"id":"2d8507a3-3a43-5ddd-aaa9-a1d5d5b3bbb0","slug":"rat-grm4","display_name":"Rat metabotropic glutamate receptor 4 / Grm4","entity_type_key":"protein"},"object":{"id":"8427ecb2-ca50-5973-907e-be8f910ed68d","slug":"rat-duodenal-epithelial-ph","display_name":"Rat duodenal epithelial intracellular pH","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f62633fa-8291-5e1b-ae06-c3b07199c653","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-duodenal-grm4-event","event_type":"observed_relationship","label":"Receptor probes help locate a step.","description":"mGluR4 agonists mimicked and an antagonist inhibited glutamate-associated pH and mucus responses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d8507a3-3a43-5ddd-aaa9-a1d5d5b3bbb0","slug":"rat-grm4","display_name":"Rat metabotropic glutamate receptor 4 / Grm4","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8427ecb2-ca50-5973-907e-be8f910ed68d","slug":"rat-duodenal-epithelial-ph","display_name":"Rat duodenal epithelial intracellular pH","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"0a3bae8e-2b2a-5622-86d8-07ede588684c","slug":"rat-duodenal-mucus-gel","display_name":"Rat duodenal mucus gel thickness","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat duodenum pharmacology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a genetic demonstration of exclusive receptor mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; 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