{"id":"17f77669-13cc-50e3-bd0b-edc79d54bf49","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-cisplatin-serotonin","predicate":"reduces","statement":"6-Gingerol treatment attenuated the cisplatin-associated rise in measured serotonin in rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"778d4c10-c9c9-5236-944f-7f25e0ca67b2","mechanism_event_label":"6-Gingerol treatment attenuated the cisplatin-associated rise in measured serotonin in rats.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"55b5ccb5-2daf-513b-942e-1fd069575708","slug":"rat-cisplatin-associated-serotonin","display_name":"Serotonin elevation in cisplatin-exposed rats","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"778d4c10-c9c9-5236-944f-7f25e0ca67b2","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-cisplatin-serotonin-event","event_type":"observed_relationship","label":"6-Gingerol treatment attenuated the cisplatin-associated rise in measured serotonin in rats.","description":"6-Gingerol treatment attenuated the cisplatin-associated rise in measured serotonin in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"55b5ccb5-2daf-513b-942e-1fd069575708","slug":"rat-cisplatin-associated-serotonin","display_name":"Serotonin elevation in cisplatin-exposed rats","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bdb83796-78cf-5b54-9ca6-4dab19b33600","slug":"cisplatin","display_name":"Cisplatin","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fef9ecc3-7c04-553c-a207-d91e38a2665a","slug":"serotonin","display_name":"Serotonin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6-Gingerol 50 or 100 mg/kg twice; cisplatin 6 mg/kg once, 1 h after first gingerol dose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Gingerol at 07:00 and 19:00; assessment 24 h after cisplatin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rats in a cisplatin-induced pica model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rats do not vomit; pica is a surrogate. This experiment does not establish human antiemetic efficacy or preserved anticancer efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rats in a cisplatin-induced pica model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"6-Gingerol treatment attenuated the cisplatin-associated rise in measured serotonin in rats.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats. (2020). https://pubmed.ncbi.nlm.nih.gov/33061309/ DOI: 10.2147/DDDT.S270185","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Gingerol gavage; cisplatin intraperitoneal injection","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Kaolin intake, ileum, medulla oblongata and serum","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"12ce96ae-390d-54a2-a847-5fd7eba13ab1","evidence_kind":"source_excerpt","locator":"Lines 547-556","start_line":547,"end_line":556,"excerpt":"## gingerols-6-cisplatin-serotonin\n6-Gingerol treatment attenuated the cisplatin-associated rise in measured serotonin in rats.\nModel/species: Rats in a cisplatin-induced pica model\nTissue: Kaolin intake, ileum, medulla oblongata and serum\nExposure: 6-Gingerol 50 or 100 mg/kg twice; cisplatin 6 mg/kg once, 1 h after first gingerol dose\nRoute: Gingerol gavage; cisplatin intraperitoneal injection\nDuration: Gingerol at 07:00 and 19:00; assessment 24 h after cisplatin\nLimits: Rats do not vomit; pica is a surrogate. This experiment does not establish human antiemetic efficacy or preserved anticancer efficacy.\nPrimary reference: [6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats. (2020). https://pubmed.ncbi.nlm.nih.gov/33061309/ DOI: 10.2147/DDDT.S270185\nAccess: Primary PubMed abstract.","model_system":"Rats in a cisplatin-induced pica model","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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