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supplementation and isotope tracing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"An engineered cancer-cell bypass is not a general epigenetic benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Acetyl-group transport can connect energy metabolism to chromatin chemistry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37134161/ · DOI 10.1126/sciadv.adf0115","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"328bc70b-122d-5466-b173-0015d7635453","evidence_kind":"source_excerpt","locator":"Lines 234-240","start_line":234,"end_line":240,"excerpt":"## l-carnitine-histone-carbon\nAcetyl-group transport can connect energy metabolism to chromatin chemistry.\nAdding acetylcarnitine increased histone acetylation in lipid-depleted mouse HCC cells lacking both ACLY and ACSS2.\nModel: Mouse hepatocellular carcinoma double-knockout cells; supplementation and isotope tracing.\nLimitations: An engineered cancer-cell bypass is not a general epigenetic benefit.\nEvidence access: Primary full-text Figure 6 and cell-line methods\nAcetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37134161/ · DOI 10.1126/sciadv.adf0115","model_system":"Mouse hepatocellular carcinoma double-knockout cells; supplementation and isotope tracing.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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